Summary
Ferritin is an iron storage protein which has been shown to be present in blood serum only recently. An immunoradiometric determination of ferritin in 324 subjects with different iron stores is reported. In healthy men and women a ferritin concentration of 131 µg/l (SD: 1,59) and 67 µg/l (SD: 1,79) was found respectively. In male and female blood donors as well as patients with iron deficiency and iron overload significant differences of serum ferritin concentration could be demonstrated. In clinical practice the determination of serum ferritin is a valuable method for the estimation of body iron stores.
Zusammenfassung
Ferritin ist ein Eisenspeicher-Protein, dessen Vorkommen im Serum erst vor wenigen Jahren nachgewiesen wurde. Es wird über die immunoradiometrische Messung von Ferritin im Serum bei insgesamt 324 Personen mit unterschiedlichem Körpereisenstatus berichtet. Der Mittelwert bei gesunden Normalpersonen beträgt für Frauen 67 µg/l (SD: 1,79) und für Männer 131 µg/l (SD: 1,59). Für männliche und weibliche Dauerblutspender sowie Patienten mit Eisenmangel bzw. Eisenüberladung wurden davon signifikant unterschiedliche Ferritinkonzentrationen im Serum gefunden. Die Bestimmung des Ferritins im Serum kann damit als wertvoller und leicht verfügbarer Parameter zur Beurteilung der Eisenspeicher angeschen werden.
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Kaltwasser, J.P., Werner, E., Kreuz, D. et al. Die radioimmunologische Messung von Ferritin im Serum und ihre klinische Bedeutung. Klin Wochenschr 55, 1103–1107 (1977). https://doi.org/10.1007/BF01477937
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DOI: https://doi.org/10.1007/BF01477937