Zusammenfassung
Wir verfolgten die 25-Hydroxy-Vitamin D- und Calciumspiegel im Serum einer Patientin mit Vitamin D-Überdosierung unter calciumsenkender Therapie über drei Monate. Normale Serumcalciumspiegel fanden sich in einem therapiefreien Intervall erst 9 Wochen nach Beendigung der Vitamin D-Einnahme. Der 25-Hydroxy-Vitamin D-Spiegel lag zu diesem Zeitpunkt mit 285 ng/ml fast um die Hälfte niedriger als zu Beginn der Beobachtungszeit drei Wochen nach Absetzen des Vitamin D.
Verlaufskontrollen der 25-Hydroxy-Vitamin D-Spiegel sind offenbar geeignet, das Ausmaß einer Vitamin D-Intoxikation abzuschätzen.
Summary
We measured the concentrations of serum calcium and 25-hydroxy-vitamin D in a patient with hypervitaminosis D during 3 months of therapy directed toward correcting the hypercalcemia. Serum calcium could not be maintained at normal concentration without specific therapy until 9 weeks after vitamin D was discontinued. Concentration of 25-hydroxy-vitamin D at the time was 285 ng/ml, approximately half of the value measured three weeks after withdrawal of vitamin D.
Serial measurements of the concentration of 25-hydroxy-vitamin D seem to be a useful means of assessing the degree of intoxication in patients with hypervitaminosis D.
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v. Lilienfeld-Toal, H., Messerschmidt, W., Sturm, B. et al. 25-Hydroxy-vitamin D levels in a patient with hypervitaminosis D. Klin Wochenschr 56, 715–717 (1978). https://doi.org/10.1007/BF02429107
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DOI: https://doi.org/10.1007/BF02429107