Zusammenfassung
Die Effekte der einzelnen Lipoproteidfraktionen des Plasmas auf die Aktivität der Lipoproteidlipase des menschlichen Fettgewebes wurden untersucht. HDL (high density lipoproteins) und, in geringerem Ausmaß, VLDL (very low density lipoproteins) bewirkten eine dosisabhängige Stimulierung der Aktivität der Lipoproteidlipase. LDL (low density lipoproteins) übten praktisch keinen Effekt aus. In höheren Konzentrationen hemmten sowohl HDL als auch VLDL die stimulierte lipolytische Aktivität. Bei Patienten mit Hyperlipoproteinämie Typ V war der stimulierende Effekt der VLDL und HDL viel geringer, die Hemmwirkung der HDL jedoch deutlich stärker ausgeprägt.
Summary
The effects of the main lipoprotein density classes on the human adipose tissue lipoprotein lipase activity were studied. A dose-dependent stimulation of lipoprotein lipase activity was obtained for HDL and, to a lesser extent, for VLDL on a constant weight basis. LDL exerted virtually no effect. At higher concentrations, HDL as well as VLDL inhibited the stimulated lipolytic activity. In type V hyperlipoproteinemia, the stimulating effect of VLDL and of HDL was significantly lower, whereas the inhibiting action of HDL was markedly increased.
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Lisch, H.J., Patsch, W., Riedler, L. et al. Activation of adipose tissue lipoprotein lipase by lipoprotein fractions from normals and patients with type V hyperlipoproteinemia. Klin Wochenschr 56, 1067–1069 (1978). https://doi.org/10.1007/BF01476554
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DOI: https://doi.org/10.1007/BF01476554