Skip to main content
SpringerLink
Log in

The renin-angiotensin-aldosterone system

Das Renin-Angiotensin-Aldosteron System

Past, present and future

  • Published:
Klinische Wochenschrift Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Monographs and Reviews

  1. Baullieu, E.E., Robel, P.: Aldosterone, Oxford: Blackwell 1964

    Google Scholar 

  2. Essential hypertension. Bock, K.D., Cottier, P.R. (eds.) Heidelberg: Springer 1960

    Google Scholar 

  3. Bumpus, F.M., Khosla, M.D.: Angiotensin analogs as determinants of the physiologic role of angiotensin and its metabolites. In: Hypertension. Genest, J., Koiw, E., Kuchel, O. (eds.); p. 183 New York: McGraw-Hill Inc. 1977

    Google Scholar 

  4. Carretero, O.A., Romero, J.C.: Production and characterization of experimental hypertension in animals. In: Hypertension. Genest, J., Koiw, E., Kuchel, O. (eds.); New York: McGraw-Hill Inc. 1977

    Google Scholar 

  5. Davis, J.O., Freeman, R.H.: Mechanisms regulating renin release. Physiol. Rev.56, 1 (1976)

    Google Scholar 

  6. Dunn, H.M., Hood, V.L.: Prostaglandins and the kidney. Am. J. Physiol.233, F 169 (1977)

    Google Scholar 

  7. Epstein, A.N.: The neuroendocrinology of thirst and salt appetite. In: Frontiers in Neuroendocrinology, Vol. 5, p. 101, Ganong, W.F., Martini, L. (eds.). New York: Raven Press 1978

    Google Scholar 

  8. Fitzsimons, J.T.: The physiological basis of thirst. Kidney Internat.10, 3 (1976)

    Google Scholar 

  9. Ganong, W.F., Forsham, P.H.: Adenohypophysis and adrenal cortex. Ann. Rev. Physiol.22, 579 (1960)

    Google Scholar 

  10. Ganten, D., Fuxe, K., Phillips, M.J., Mann, J.F.E., Ganten, U.: The brain iso-renin-angiotensin system: Biochemistry, localization and possible role in drinking and blood pressure regulation. In: Frontiers in Neuroendocrinology, Vol. 5, Chapter 3, p. 61, Ganong, W.F., Martini, L. (eds.) New York: Raven Press: 1978b

    Google Scholar 

  11. Ganten, D., Gross, F.: Interferences with the renin angiotensin system and their effects on high blood pressure. In: Antihypertensive agents. Handbook of Experimental Pharmacology Vol. XXXIV, p. 517, Gross, F. (ed.). Heidelberg: Springer 1977

    Google Scholar 

  12. Ganten, D., Hutchinson, J.S., Schelling, P., Ganten, U., Fischer, H.: The iso-renin angiotensin systems in extrarenal tissue. Clin. Exp. Pharmacol. Physiol.2, 103 (1976a)

    Google Scholar 

  13. Genest, J., Koiw, E. (eds.): Hypertension 1972, Berlin-Heidelberg-New York: Springer 1972

    Google Scholar 

  14. Genest, J., Koiw, E., Küchel, O.: Hypertension. New York: McGraw-Hill 1977

    Google Scholar 

  15. Genest, J., Nowaczynski, W., Küchel, O., Boucher, R., Rojo-Ortega, J.M., Constantopoulos, G., Ganten, D., Messerli, F.: The adrenal cortex and essential hypertension. Recent progress in hormone research, Vol. 32, p. 377, New York: Academic Press 1976

    Google Scholar 

  16. Gláz, E., Vecsei, P.: Aldosterone. Oxford: Pergamon Press 1971

    Google Scholar 

  17. Goodfriend, T.L., Fyhrquist, F., Allman, D.: Biochemical effects of angiotensin. Handbuch der experimentellen Pharmakologie Vol. XXXVII, p. 511, Page, I.H., Bumpus, F.M. (eds.). Heidelberg: Springer 1974

    Google Scholar 

  18. Gross, F.: Angiotensin. In: Pharmacology of Naturally Occurring Polypeptides and Lipid-Soluble Acids. Intern. Encyclopedia of Pharmacology and Therapeutics, Walker, J.M. (ed.), p. 73. Oxford: Pergamon Press 1971

    Google Scholar 

  19. Khairallah, P.A.: Pharmacology of angiotensin. In: Kidney Hormones, Academic Press: London, New York 1971

    Google Scholar 

  20. Lee, M.R.: Renin and hypertension. London: Lloyd-Luke, 1969

    Google Scholar 

  21. Malvin, R.L.: Angiotensin and antidiuretic hormone. In: Endocrinology, Scow, R.O. (ed.), p. 717. New York: American Elsevier 1973

    Google Scholar 

  22. Müller, J.: Regulation of aldosterone biosynthesis. Heidelberg-New York: Springer 1971

    Google Scholar 

  23. Muller, O'Connor (eds.): An International Symposium on Aldosterone. London: Churchill 1958

    Google Scholar 

  24. Oparil, S.: Renin 1976. In: Annual Research Reviews, Horrobin, D.F. (ed.). Montreal: Eden Press 1976

    Google Scholar 

  25. Page, I.H., Bumpus, F.M.: Angiotensin. In: Handbook of experimental pharmacology. Vol. XXXVII, Berlin-Heidelberg-New York: Springer 1974

    Google Scholar 

  26. Page, J.H., McCubbin, J.W. (eds.): Renal hypertension. Year Book Medical Publishers 1968

  27. Peach, M.: Renin-angiotensin system: Biochemistry and mechanism of action. Physiol. Rev.57, 313 (1977)

    Google Scholar 

  28. Reid, I.A., Morris, B.J., Ganong, W.F.: The renin-angiotensin system. Ann. Rev. Physiol.40, 377 (1978)

    Google Scholar 

  29. Ross, E.J.: Aldosterone and aldosteronism. London: Lloyd-Luke 1975

    Google Scholar 

  30. Ross, E.J.: Aldosterone in clinical and experimental medicine. Oxford: Blackwell 1959

    Google Scholar 

  31. Severs, W.B., Daniels-Severs, A.E.: Effects of angiotensin on the central nervous system. Pharmacol. Rev.25, 415 (1973)

    Google Scholar 

  32. Thurau, K., Mason, J.: The internal function of the juxtaglomerular apparatus. MTP-Internat. Rev. of Science. Physiology Ser. 1, Vol. 6, Kidney and Urinary Tract, Physiology, Thurau K. (ed.), p. 357. London: Butterworth 1974

    Google Scholar 

  33. Werning, C.: Das Renin-Angiotensin-Aldosteron System. Stuttgart: Thieme 1972

    Google Scholar 

  34. Zanchetti, A., Stella, A., Leonetti, G., Morganti, A., Terzoli, L.: Control of renin release: A review of experimental evidence and clinical implications. Am. J. Cardiol.37, 675 (1976)

    Google Scholar 

References

  1. Adlercreutz, H.: Lecture at the International Congress of Clinical Chemistry. Mexico City, March 1978

  2. Adlercreutz, H.: Use of mass spectrometry for clinical endocrinology. J. Steroid Biochem.8, IV (1977)

    Google Scholar 

  3. Adlercreutz, H., Hekali, R., Wahlroos, Ö.: New urinary steroid in hypertension. Brit. Med. J.2, 499 (1973)

    Google Scholar 

  4. Akesode, A., Hendler, N., Kowarski, A.: 1 24 h monitoring of the integrated plasma concentration of aldosterone and cortisol in manic patients. Psychoneuroendocrinology1, 419 (1976)

    Google Scholar 

  5. Al-Dujaili, E.A.S., Edwards, C.R.W.: The development and application of a direct radioimmunoassay for plasma aldosterone using125I-labelled ligand-comparison of three methods. J. Clin. Endocrinol.46, 105 (1978)

    Google Scholar 

  6. Allman, D.W., Goodfriend, T.: The role of endogenous free fatty acids in regulating mitochondrial function. In: Proc. First Europ. Biophys. Congr., Berlin-Heidelberg-New York: Springer-Lederer 1971

    Google Scholar 

  7. Angles D'Auriac, G., Baudouin, M., Meyer, P.: Mechanisms of action of angiotensin in smooth muscle cell; biochemical changes following the interaction of the hormone with its membrane receptors. Circ. Res.31, II-151 (1972)

    Google Scholar 

  8. Angles D'Auriac, G., Meyer, P.: Effects of angiotensin II on adenylcyclase activity, phosphodiesterase activity and on the level of cyclic AMP in rat uterus. Clin. Sci. Mol. Med.45, 247s (1973)

  9. Atlas, S.A., Sealey, J.E., Laragh, J.H.: Dependency of acid and cryoactivation of inactive plasma renin on prior activation of a neutral serim protease. Kidney Internat.12, 495 (1977)

    Google Scholar 

  10. Bangham, D.R., Robertson, I., Robertson, J.I.S., Robinson, C.J., Tree, M.: An international collaborative study of renin assay. Establishment of the international reference preparation of human renin. Clin. Sci. Mol. Med.48, 135 s (1975)

    Google Scholar 

  11. Bartter, F.C., Pronive, P., Gill, J.R., McCardle, R.C.: Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis. Am. J. Med.33, 881 (1962)

    Google Scholar 

  12. Baudouin, M., Meyer, P., Fermandjian, S., Morgat, J.L.: Calcium release induced by interaction of angiotensin with its receptors in smooth muscle microsomes. Nature (Lond.)235, 336 (1972)

    Google Scholar 

  13. Bayard, F., Beitins, I.Z., Kowarski, A., Migeon, C.J.: Measurement of aldosterone secretion rate by radioimmunoassay. J. Clin. Endocrinol.31, 507 (1970)

    Google Scholar 

  14. Biglieri, E.G.: A perspective on aldosterone abnormalities. Clin. Endocrinol.5, 399 (1976)

    Google Scholar 

  15. Blair-West, J.R., Coghlan, J.P., Denton, D.A., Funder, J.W., Scoggins, B.A., Wright, R.D.: Effect of the heptapeptide (2–8) and hexapeptide (3–8) fragments of angiotensin II on aldosterone secretion. J. Clin. Endocrinol.32, 575 (1971)

    Google Scholar 

  16. Blair-West, F.R., Coghlan, J.P., Denton, D.A., Goding, J.R., Wintour, M., Wright, R.D.: The control of aldosterone secretion. Recent Prog. Horm. Res.19, 311 (1963)

    Google Scholar 

  17. Boadle, M.C., Hughes, J., Roth, R.H.: Angiotensin accelerates catecholamine biosynthesis in sympathetically innervated tissues. Nature222, 987 (1969)

    Google Scholar 

  18. Boadle, M.C., Roth, R.H.: Effects of angiotensin II and angiotensin III on catecholamine biosynthesis. In: Central Actions of Angiotensin and Related Hormones. Buckly, J.P., Ferrario, C.M. (eds.), p. 83. Oxford: Pergamon Press 1977

    Google Scholar 

  19. Bonjour, J.P., Malvin, R.L.: Stimulation of ADH release by the renin-angiotensin system. Am. J. Physiol.218, 1555 (1970)

    Google Scholar 

  20. Boucher, R., Veyrat, R., Champlein de, J., Genest, J.: New procedure for measurement of human plasma angiotensin and renin activity levels. Can. Med. Ass. J.90, 194 (1963)

    Google Scholar 

  21. Brown, J.J., Davies, D.L., Fraser, R., Robertson, J.I.S., Chinn, R.H., Düsterdieck, G., Lever, A.F., Tree, M., Wiseman, A.: Plasma electrolytes, renin, and aldosterone in the diagnosis of primary hyperaldosteronism. Lancet2, 55 (1968)

    Google Scholar 

  22. Brown, J.J., Davies, D.L., Lever, A.F., Robertson, J.I.S.: Variations in plasma renin concentration in several physiological and pathological states. Can. Med. Ass. J.90, 201 (1963)

    Google Scholar 

  23. Brown, J.J., Fraser, R., Lever, A.F., Morton, J.J., Robertson, J.I.S., Tree, M., Bell, P.R.F., Davidson, J.K., Ruthven, I.S.: Hypertension and secondary hyperaldosteronism associated with a renin-secreting renal juxta-glomerular cell tumor. Lancet2, 1228 (1973)

    Google Scholar 

  24. Brown, D.R., Swandler, A., McKenzie, J.K.: Urine aldosterone radioimmunoassay: Validation of a method without chromatography. J. Clin. Endocrinol.42, 894 (1976)

    Google Scholar 

  25. Bumpus, F.M., Smeby, R.R., Page, I.H., Khairallah, P.A.: Distribution and metabolic fate of angiotensin II and various derivatives. Can. Med. Ass. J.90, 190 (1964)

    Google Scholar 

  26. Campbell, W.B., Brooks, S.N., Pettinger, W.A.: Angiotensin II and angiotensin III induced aldosterone release in vivo in the rat. Science184, 994 (1974)

    Google Scholar 

  27. Capponi, A.M., Valloton, M.B.: Renin release by rat kideny slices incubated in vitro. Role of sodium and of α- and β-adrenergic receptors, and effect of vincristine. Circ. Res.39, 200 (1976)

    Google Scholar 

  28. Carpenter, C.J., Davis, J.O., Ayers, C.R.: Relation of renin, angiotensin II, and experimental renal hypertension to aldosterone secretion. J. Clin. Invest.40, 2026 (1961)

    Google Scholar 

  29. Catt, K.H., Glossman, H., Baukal, A.: Angiotensin II receptors of the adrenal cortex. Exc. Med. Int. Cong. Ser.302, 200 (1973)

    Google Scholar 

  30. Chandler, D.W., Tuck, M., Mayes, D.M.: The measurements of 18-hydroxy-11-deoxycorticosterone in human plasma by radioimmunoassay. Steroids27, 235 (1976)

    Google Scholar 

  31. Coghlan, J.P., Denton, D.A., Fan, J.S.K., McDougall, J.G., Scoggins, B.A., Shulkes, A.A.: Further unravelling of the causes of ACTH-induced hypertension in the sheep. Clin. Sci. Mol. Med.51, (Suppl. 3) 295 (1976)

    Google Scholar 

  32. Coghlan, J.P., Denton, D.A., Goding, J.R., Wright, R.D.: The control of aldosterone secretion. Postgrad. Med. J.36, 76 (1960)

    Google Scholar 

  33. Cohen, S., Taylor, J.M., Murakami, K., Michelakis, A.M., Inagami, T.: Isolation and characterization of renin-like enzymes from mouse submaxillary glands. Biochemistry11, 4286 (1972)

    Google Scholar 

  34. Conn, J.W., Cohen, E.L., Lucas, C.P., McDonald, W.J., Mayor, G.H., Blough, Jr., W.M., Eveland, W.C., Bookstein, J.J., Lapides, J.: Primary reninism. Hypertension, hyperreninemia, and secondary aldosteronism due to renin-producing juxtaglomerular cell tumors. Arch. Intern. Med.,130, 682 (1972)

    Google Scholar 

  35. Conn, J.W., Cohen, E.L., Rovner, D.R.: Suppression of plasma renin activity in primary aldosteronism. JAMA190, 213 (1964)

    Google Scholar 

  36. Constantinides, P., Robinson, M.: Ultrastructural injury of arterial endothelium. Arch. Path.88, 99 (1969)

    Google Scholar 

  37. Cope, C.L., Loizou, S.: Simplification of urinary aldosterone measurement by radioimmunoassay. J. Clin. Path.26, 628 (1973)

    Google Scholar 

  38. Cosby, L.A., Sartorelli, A.C., Roth, R.H.: Studies on angiotensin-induced synthesis of aldosterone in rabbit adrenal slices. Pharmacologist13, 214 (1971)

    Google Scholar 

  39. Coviello, A., Crabbé, J.: Effect of angiotensin II on active transport of sodium by toad bladder and skin. Biochem. Pharmacol.14, 1739 (1965)

    Google Scholar 

  40. Crocker, A.D., Munday, K.A.: Aldosterone and angiotensin action on water absorption in rat jejunum. J. Physiol.192, 36 (1967)

    Google Scholar 

  41. Crocker, A.D., Munday, K.A.: The effect of the renin-angiotensin system on mucosal water and sodium transfer in everted sacs of rat jejunum. J. Physiol.206, 323 (1970)

    Google Scholar 

  42. Dale, S.L., Melby, J.C.: Isolation and identification of 16, 18-dihydroxydeoxycorticosterone from human adrenal gland incubations. Steroids21, 617 (1973)

    Google Scholar 

  43. Daniels, A.E., Severs, W.B., Buckley, J.P.: The effects of angiotensin II on the43Ca distribution of the rat. Life Sci.6, 545 (1967)

    Google Scholar 

  44. Davies, N.T., Munday, K.A., Parsons, B.J.: Dose-dependent biphasic effects of angiotensin on fluid transfer by rat colon. J. Physiol. (Lond.)204, 142 P (1969)

    Google Scholar 

  45. Davies, N.T., Munday, K.A., Parsons, B.J.: The effect of angiotensin on the rat intestinal fluid transfer. J. Endocrinol.48, 39 (1970)

    Google Scholar 

  46. Davies, N.T., Munday, K.A., Parsons, B.G.: The effects of protein synthesis inhibitors on angiotensin stimulated colonic fluid transfer. J. Physiol. (Lond.)205 (abstract), 17 P (1969)

    Google Scholar 

  47. Davis, J.O.: Mechanisms regulating the secretion and metabolism of aldosterone in experimental secondary hyperaldosteronism. Rec. Prog. Horm. Res.17, 293 (1961)

    Google Scholar 

  48. Davis, J.O., Carpenter, C.C.J., Ayers, C.R., Holman, J.E., Bahn, R.C.: Evidence for secretion of an aldosterone-stimulating hormone by the kidney. J. Clin. Invest.40, 684 (1961)

    Google Scholar 

  49. Davis, J.O., Freeman, R.H., Johnson, J.A., Spielman, W.S.: Agents which block the action of the renin-angiotensin system. Circ. Res.,34, 279 (1974)

    Google Scholar 

  50. Deane, H.W., Masson, G.M.C.: Adrenal cortical changes in rats with various types of experimental hypertension. J. Clin. Endocrinol.11, 193 (1951)

    Google Scholar 

  51. Deane, H.W., Show, J.H., Greep, R.O.: The effect of altered sodium and potassium intake on the width and cytochemistry of the zona glomerulosa of the rats adrenal cortex. Endocrinology43, 133 (1948)

    Google Scholar 

  52. Denae, H.W., Barger, A.C.; cit.: Barger, A.C.: Histophysiology of adrenal cortex in dogs with mild and severe cardiac damage. Endocrinology61, 758 (1957)

    Google Scholar 

  53. Deck, K.A., Champoin, P.K., Conn, J.W.: Urinary free aldosterone in healthy people and in patients with primary aldosteronism. J. Clin. Endocrinol.36, 756 (1973)

    Google Scholar 

  54. Delasalle, A., Gesselin, F., Carayon, A., Legrand, S., Antreassian, J., Lagoguey, A., Legrand, C.J., Desgrez, P.: Radioimmunological determination of urinary tetrahydroaldosterone. Steroids29, 725 (1977)

    Google Scholar 

  55. Derkx, F.H.M., v. Gool, J., Wenting, G.J., Verhoeven, R.P., Man in't Veld, A.J., Schalekamp, M.A.D.H.: Inactive renin in human plasma. LancetII, 496 (1976)

    Google Scholar 

  56. Devynck, M.A., Meyer, P.: Angiotensin receptors in vascular tissue. Amer. J. Med.61, 758 (1976)

    Google Scholar 

  57. Dunihue, F.W.: The effect of adrenal insufficiency and of desoxycorticosterone acetate on the juxtaglomerular apparatus. Anat. Rec.103, 442 (1949)

    Google Scholar 

  58. Dunihue, F.W., Robertson, W.V.B.: Effect of desoxycorticosterone acetate and of sodium on juctaglomerular apparatus. Endocrinology61, 293 (1957)

    Google Scholar 

  59. Dustan, H.P., Masson, G.M.C.: Contribution of the adrenal cortex to renal and renoprival hypertension. Circ. Res.17, 765 (1958)

    Google Scholar 

  60. Elie, R., Panisset, J.-C.: Effect of angiotensin and atropine on the spontaneous release of acetylcholine from cat cerebral cortex. Brain Res.17, 297 (1970)

    Google Scholar 

  61. Eskildsen, P.C.: Renin in the female genital tract. Kopenhagen, Arhus, Odense: Forlag F.A.D.L.'s 1974

    Google Scholar 

  62. Ferris, T.F., Gorden, P., Mulrow, P.J.: Rabbit uterus as a source of renin. Am. J. Physiol.212, 698 (1967)

    Google Scholar 

  63. Fischer-Ferraro, C., Nahmod, V.E., Goldstein, D.J., Finkielman, S.: Angiotensin and renin in rat and dog brain. J. Exp. Med.,133, 353 (1971)

    Google Scholar 

  64. Fisher, J.W., Roh, B.L.: Factors influencing renal and extrarenal erythropoetin production. In: Renal Pharmacology. New York: Appleton-Centry-Crofts 1971

    Google Scholar 

  65. Forssmann, W.G., Taugner, R.: Studies on the juxtaglomerular apparatus.\(\bar V\) The juxtaglomerular apparatus in Tupaia with special reference to intracellular contact. Cell. Tiss. Res.177, 291 (1977)

    Google Scholar 

  66. Fraser, R.: The influence of sodium status and of ACTH on the effect of angiotensin II on plasma. Corticosteroid concentrations in man: some implications in the control of corticosteroid biosynthesis. The endocrine function of the human adrenal cortex. Abstracts. Florence 1977

  67. Fraser, R., James, V.H.T., Brown, J.J., Isaac, P., Lever, A.F., Robertson, J.I.S.: Effect of angiotensin and furosemide on plasma aldosterone, corticosterone, cortisol and renin in man. LancetII, 989 (1965)

    Google Scholar 

  68. Gagnon, D.J., Cousineau, D., Boucher, P.J.: Release of vasopressin by angiotensin II and prostaglandin E2 from the rat neurohypophysis in vitro. Life Sci.,12, 487 (1973)

    Google Scholar 

  69. Ganong, W.F., Mulrow, P.J.: Evidence of secretion of an aldosterone-stimulating substance by the kidney. Nature190, 1115 (1961)

    Google Scholar 

  70. Ganten, D., Kusumoto, M., Constantopoulos, G., Ganten, U., Boucher, R., Genest, J.: Iso-renin, electrolytes and catecholamines in dog brain: Possible interrelationship. Life Sci.,12, 1 (1973)

    Google Scholar 

  71. Ganten, D., Schelling, P., Vecsei, P., Ganten, U.: Iso-renin of extrarenal origin. The tissue angiotensinogenase systems. Amer. J. Med.60, 760 (1976)

    Google Scholar 

  72. Genest, J., Nowaczynski, W., Koiw, E., Sandor, T., Biron, P.: Adrenocortical function in essential hypertension. In: Essential Hypertension. Bock, K.D., Cottier, P.R. (eds.), Heidelberg: Springer 1960

    Google Scholar 

  73. Genest, J., Rojo-Ortega, J.M., Küchel, O., Boucher, R., Nowaczynski, W., Lefebvre, R., Chrétien, M., Contrin, J., Granger, P.: Malignant hypertension with hypokaliemia in a patient with renin-producing pulmonary careinoma. Transact. Assoc. Amer. Physic.88, 192 (1975)

    Google Scholar 

  74. Gill, J.R., Fröhlich, J.C., Bowden, R.E., Taylor, A.A., Keiser, H.R., Seyberth, H.W., Oates, J.A., Bartter, F.C.: Bartter's syndrome: A disorder characterized by high urinary prostaglandins and a denpende of hyperreniemia on prostaglandin synthesis. Amer. J. Med.61, 43 (1976)

    Google Scholar 

  75. Gill, G.N., Jel, C.R., Simonian, M.H.: Angiotensin stimulation of adrenocortical cell growth. Proc. Natl. Acad. Sci. USA74, 5569 (1977)

    Google Scholar 

  76. Gomez-Sanchez, C.E., Holland, O.B., Lloyd, H.A., Milewich, L.: New mineralocorticoid in adrenal regeneration hypertension. Clin. Res.36, 15A (1978)

  77. Gomez-Sanchez, C.E., Kem, D.C., Kaplan, N.M.: A radioimmunoassay for plasma aldosterone by immunologic purification. J. Clin. Endocrinol.36, 795 (1973)

    Google Scholar 

  78. Gomez-Sanchez, C.E., Milewich, L., Holland, O.B.: Radioiodinated derivatives for steroid radioimmunoassay. Application to the radioimmunoassay of cortisol. J. Lab. Clin. Med.89, 902 (1977)

    Google Scholar 

  79. Goodfriend, T.L.: Receptors for angiotensins. In: Hypertension, Genest, J., Koiw, E., Kuchel, O. (eds.), p. 173, 1977

  80. Goormaghtigh, N., Handovsky, H.: Effect of vitamin D2 (calciferol) in the dog. Arch. Pathol.26, 114 (1938)

    Google Scholar 

  81. Gross, F.: Steuerung der Aldosteronsekretion. Schweiz. Med. Wochenschr.89, 1 (1959)

    Google Scholar 

  82. Gross, F.: Renin und Hypertensin, physiologische oder pathologische Wirkstoffe? Klin. Wochenschr.36, 193 (1958)

    Google Scholar 

  83. Gross, F., Lichtlen, P.: Pressor substances in kidneys of renal hypertensive rats with and without adrenals. Proc. Soc. Exp. Biol. Med.98, 341 (1958)

    Google Scholar 

  84. Gross, F., Loustalot, P., Sulser, F.: Die Bedeutung von Kochsalz für den Cortexon-Hochdruck der Ratte und den Gehalt der Nieren an pressorischen Substanzen. Arch. exp. Path. Pharmakol.229, 381 (1958)

    Google Scholar 

  85. Gross, F., Sulser, F.: Pressorische Substanzen in den Nieren experimentell hypertonischer Ratten. Arch. exp. Path. Pharmakol.229, 374 (1956)

    Google Scholar 

  86. Gutman, Y., Shamir, Y., Glushevitzky, D., Hochman, S.: Angiotensin increases microsomal (Na+ -K+) ATPase activity in several tissues. Biochim. Biophys. Acta273, 401 (1972)

    Google Scholar 

  87. Hackenthal, E., Bauknecht, H., Oster, P.: The response of the renin-angiotensin system in rats to the injection of angiotensin II antibodies. Clin. Sci. Mol. Med.48, 27s (1975)

  88. Hackenthal, E., Hackenthal, R., Hilgenfeldt, U.: Iso-renin, pseudo-renin, cathepsin D and renin. A comparative enzymatic study of angiotensin forming enzymes. Biochim. Biophys. Acta522, 574 (1978)

    Google Scholar 

  89. Hackenthal, E., Hackenthal, R., Hilgenfeldt, U.: Purification and partial characterization of rat brain acid proteinase (isorenin). Biochim. Biophys. Acta522, 561 (1978)

    Google Scholar 

  90. Hackenthal, E., Schwertschlag, U., Hackenthal, R.: The influence of vinblastine and colchicine on renin secretion in vivo and in vitro. Klin. Wochenschr.56, (Suppl. I) 61–66 (1978)

    Google Scholar 

  91. Hartroft, P.M., Hartroft, W.S.: Studies on renal juxtaglomerular cells. I. Variations produced by sodium chloride and desoxycorticosterone acetate. J. Exp. Med.97, 415 (1953)

    Google Scholar 

  92. Hartroft, P.M., Hartroft, W.S.: Studies on renal juxtaglomerular cells. II. Correlation of the degree of granulation of juxtaglomerular cells with width of the zona glomerulosa of the adrenal cortex. J. Exp. Med.102, 205 (1955)

    Google Scholar 

  93. Hayduk, K., Ganten, D., Boucher, R., Genest, J.: Arterial and urinary renin activity. In: Hypertension 1972, Genest J., Koiw, E., (eds.), p. 435, Berlin-Heidelberg-New York: Springer 1972

    Google Scholar 

  94. Heidenreich, O., Kook, Y., Baumeister, L., Reus, E.: Stoffwechselwirkungen von synthetischem Angiotensin II. Arch. int. Pharmacodyn.148, 309 (1964)

    Google Scholar 

  95. Helmer, O.H.: Renin activity in blood from patients with hypertension. Can. Med. Ass. J.90, 221 (1963)

    Google Scholar 

  96. Hofbauer, K.G., Konrads, A., Schwarz, K., Werner, U.: Effect of cyclic AMP on renin release in the isolated perfused rat kidney. Klin. Wochenschr.56 (1978)

  97. Hollifield, J.W., Slaton, P.E., Wilson, H.M., Sennett, J.A., Yarbro, L., Island, D.P., Liddle, G.W.: Are there unknown mineralocorticoids in low-renin essential hypertension? Mayo Clin. Proc.52, 329 (1977)

    Google Scholar 

  98. Hornung, J., Gless, K.H., Abdelhamid, S., Vielhauer, W., Vecsei, P.: Radioimmunoassay of free urinary 18-OH-desoxy-corticosterone(18-OH-DOC). Acta Endocr. (Kbh)85, (Suppl. 212) 201 (1977)

    Google Scholar 

  99. Hornung, J., Gless, K.H., Abdelhamid, S., Vielhauer, S., Vecsei, P.: Radioimmunoassay of free urinary 18-hydroxydesoxy-corticosterone (18-OH-DOC) in patients with essential hypertension. Clin. Chim. Acta87, 181 (1978)

    Google Scholar 

  100. Hornych, A., Meyer, P., Milliez, P.: Angiotensin, vasopressin and cyclic AMP: effects on sodium and water fluxes in rat colon. Am. J. Physiol.224, 1223 (1973)

    Google Scholar 

  101. Hubl, W., Stahl, F., Büchner, M., Garten, C.D.: A direct radioimmunoassay for free aldosterone in urine without extraction and chromatography. Endokrinologie68, 283 (1976)

    Google Scholar 

  102. Hudson, J.B., Chobanian, A.V., Relman, A.S.: Hypoaldosteronism. A clinical study of a patient with an isolated adrenal mineralocorticoid deficiency resulting in hyperkalemia and Stokes-Adams attacs. New Eng. J. Med.257, 529 (1957)

    Google Scholar 

  103. Hughes, J., Roth, H.R.: Evidence that angiotensin enhances transmitter release during sympathic nerve stimulation. Biol. J. Pharmacol.41, 239 (1971)

    Google Scholar 

  104. Huruyama, K., Nakajima, K., Fukuchi, S., Saito, M., Iinuma, K.: A simple method measuring plasma aldosterone by radioimmunoassay without extraction. Nippon Naibunpi Gakkai Zassh53, 810 (1977)

    Google Scholar 

  105. Inagami, T., Hirose, S., Morita, N., Ito, H., Okamoto, K., Suzuki, F.: Renin in SHR and SHRSP: Molecular studies. Abstracts Third International Symposium: Spontaneously Hypertensive Rats and Related Studies. Kyoto, Japan, Sept. 13, 1978

  106. Inagami, T., Misono, K., Michelakis, A.M.: Definitive evidence for similarity in the active site of renin and acidic protease. Biochem. Biophys. Res. Commun.56, 503 (1974)

    Google Scholar 

  107. Inagami, T., Murakami, K.: Pure renin: Isolation from hog kidney and characterization. J. Biol. Chem.252, 2978 (1977)

    Google Scholar 

  108. Inagami, T., Murakami, K.: Purification of high molecular weight froms of renin from hog kidney. Circ. Res.41, (Suppl. 2) II-11 (1977)

    Google Scholar 

  109. Jowett, T.P., Slater, J.D.H., Piyasema, R.D., Ekins, R.P.: Radioimmunoassay of aldosterone in plasma and urine: Validation of the novel separation technique and a rapid urine assay. Clin. Sci. Mol. Med.45, 607 (1973)

    Google Scholar 

  110. Kaplan, N., Bartter, F.C.: The effect of ACTH, renin, angiotensin II, and various precursors on biosynthesis of aldosterone by adrenal slices. J. clin. Invest.41, 715 (1962)

    Google Scholar 

  111. Keil, L.C., Summy-Long, J., Severs, W.B.: Release of vasopressin by angiotensin II. Endocrinology96, 1063 (1975)

    Google Scholar 

  112. Khairallah, P.A.: Action of angiotensin on adrenergic nerve endings: Inhibition of noreprinephrine uptake. Fed. Proc.31, 1351 (1972)

    Google Scholar 

  113. Khairallah, P.A., Khosla, M.C., Bumpus, F.M., Tait, J.F., Tait, S.A.S.: Biological activity of angiotensin. V. Scientific Meeting of the International Society of Hypertension, Paris, 1978

  114. Khairallah, P.A., Robertson, A.L., Jr., Davila, D.: Effects of angiotensin II on DNA, RNA and protein synthesis. In: Hypertension 1972. Genest, J., Koiw, L. (eds.), p. 212, Berlin, Heidelberg, New York:: Springer 1972

    Google Scholar 

  115. Kohl, K.H., Vecsei, P., Abdelhamid, S.: Radioimmunoassay of tetrahydroaldosterone (TH-Aldo) in human urine. Acta Endocrinol. (Kbh)87, 596 (1978)

    Google Scholar 

  116. Langan, J., Jackson, R., Adlin, E.V., Chanick, B.J.: A simple radioimmunoassay for urinary aldosterone. J. Clin. Endocrinol.38, 189 (1974)

    Google Scholar 

  117. Laragh, J.H., Angers, M., Kelly, W.G., Liebermann, S.: Hypotensive agents and pressor substances. The effect of epinephrine, norepinephrine, angiotensin II and others on the secretory rate of aldosterone in man. JAMA17, 234 (1960)

    Google Scholar 

  118. Laragh, J.H., Sealey, J.E., Sommers, S.C.: Patterns of adrenal secretion and urinary excretion of aldosterone and plasma renin activity in normal and hypertensive subjects. (Suppl.) Circ. Res.18, 158 (1966)

    Google Scholar 

  119. Laragh, J.H., Ulick, S., Januszewicz, V., Deming, Q.B., Kelly, W.G., Liebermann, S.: Aldosterone secretion and primary and malignant hypertension. J. Clin. Invest.39, 1091 (1960)

    Google Scholar 

  120. Lechi, A., Covi, G., Lechi, C., Mantero, F., Scuro, L.A.: Urinary kallikrein excretion in Bartter's syndrome. J. Clin. Endocrinol. Metabol.43, 1175 (1976)

    Google Scholar 

  121. Levin, K.: The stimulating effect of angiotensin and vasopressin on adenosine triphosphatase activity in vitro. Acta physiol. scand.79, 37 (1970)

    Google Scholar 

  122. Leyssac, P.P.: Quantitative estimates of the routes of renin release at the individual nephron level in vivo. Proc. Int. Congress of Nephrology, Abstract T1, Montreal, 1977

  123. Lommer, D., Wolff, H.P.: Stimulation of the in vitro biosynthesis of corticosteroids by angiotensin II. Experientia22, 699 (1966)

    Google Scholar 

  124. Malik, K.U., Nasjletti, A.: Facilitation of adrenergic transmission by locally generated angiotensin II in rat mesenteric arteries. Circ. Res.38, 26 (1976)

    Google Scholar 

  125. Martin, V.I., Edwards, C.R.W., Biglieri, E.G., Vinson, G.P., Bartter, F.C.: The development and application of a radioimmunoassay for 18-hydroxy-corticosterone. Steroids26, 591 (1975)

    Google Scholar 

  126. Marver, D., Edelman, I.S.: Dihydrocortisol: A potential mineralocorticoid. J. Steroid Biochem.9, 1 (1977)

    Google Scholar 

  127. McAfee, R.D., Locke, W.: Effect of angiotensin amide on sodium isotope flux and short circuit current of isolated frog skin. Endocrinology81, 1301 (1967)

    Google Scholar 

  128. McCaa, R.E., Young, D.B., Guyton, A.C., McCaa, C.S.: Regulation of aldosterone secretion. Role for a non-ACTH pituitary factor during alterations in sodium balance. In: Breuer, H., Hughes, A., Klopper, A., Conti, C., Jungblut, P., Lerner, L. (eds.). Research on steroids. Trans. VI. Meeting of the International Study Groups for Steroid Hormones. Vol. VI, p. 195. New York: North Holland 1975

    Google Scholar 

  129. McGiff, J.C., Crowshaw, K., Terragno, N.A., Lonigro, A.J.: Release of a prostaglandin-like substance into renal venous blood in response to angiotensin II. In: Hypertension, Vol. XVIII. Mechanisms of Hypertension. New York: Am. Heart Ass. 1970

    Google Scholar 

  130. McKenzie, J.K., Clemens, J.A.: Simplified radioimmunoassay for serum aldosterone utilizing increased antibody specificity. J. Clin. Endocrinol.38, 622 (1974)

    Google Scholar 

  131. Menzie, J.W., Michelakis, A.M., Yoshida, H.: Sympathetic nervous system and renin release from submaxillary glands and kidneys. Am. J. Physiol.6, 1281 (1974)

    Google Scholar 

  132. Melby, J.C., Dale, S.L.: Role of 18-hydroxy-11-deoxycorticosterone and 16, 18-dihydroxy-11-deoxycorticosterone in hypertension. Mayo Clin. Proc.52, 317 (1977)

    Google Scholar 

  133. Melby, J.C., Dale, S.L., Grekin, R.J., Gaunt, R., Wilson, T.E.: 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) secretion. Rec. Progr. Horm. Res.18, 287 (1972)

    Google Scholar 

  134. Minnich, J.L., Donaldson, J., Barbeau, A.: Modification des concentrations régionales des monoamines cerebrales par l'angiotensine. L'Union Med. du Can.102, 903 (1973)

    Google Scholar 

  135. Moncada, S., Herman, A.G., Higgs, E.A., Vane, J.R.: Differential formation of prostacyclin (PG or PGI2) by layers of the arterial wall. An explanation for the antithrombolic properties of vascular endothelium. Thromb. Res.11, 323 (1977)

    Google Scholar 

  136. Morgan, T., Davis, J.M.: Renin secretion at the individual nephron level. Pflügers Arch. Res. Physiol.359, 23 (1975)

    Google Scholar 

  137. Morgan, J.M., Routtenberg, A.: Angiotensin injected into the neostriatum after learning disrupts retention performance. Science196, 87 (1977)

    Google Scholar 

  138. Müller, J., Gross, F.: Effects of experimental renal hypertension on aldosterone biosynthesis by rat adrenal tissue. Acta Endocrinol. (Kbh.)60, 669 (1969)

    Google Scholar 

  139. Munday, K.A., Parsons, B.J., Poat, J.A.: Studies on the mechanism of action of angiotensin on ion transport by kidney cortex slices. J. Physiol. (Lond.)224, 195 (1972)

    Google Scholar 

  140. Munday, K.A., Parsons, B.J., Poat, J.A.: The effect of angiotensin on cation-transport by rat kidney cortex slices. J. Physiol. (Lond.)215, 269 (1971)

    Google Scholar 

  141. Nasjletti, A., Masson, G.M.C.: Stimulation of angiotensinogen formation by renin and angiotensin I. Proc. Soc. Exp. Biol. Med.,142, 307 (1973)

    Google Scholar 

  142. Nasjletti, A., Masson, G.M.C.: Studies on angiotensinogen formation in a liver perfusion system. Circ. Res.30, 187 (1972)

    Google Scholar 

  143. Ølgaard, K., Madsen, S., Hammer, M., Ladefoged, J.: Calcium dependent aldosterone secretion in anephric and non-nephrectomized patients on regular hemodialysis. J. Clin. Endocrinol. Metabol.46, 740 (1978)

    Google Scholar 

  144. Ondetti, M.A., Rubin, B., Cushman, D.W.: Design of specific inhibitors of angiotensin converting enzyme: New class of orally active antihypertensive agents. Science196, 441 (1977)

    Google Scholar 

  145. Padfield, P.L., Beevers, D.G., Brown, F.J., Davies, D.L., Lever, A.F., Robertson, J.I.S., Schalekamp, M.A.D., Tree, M.: Is lowrenin hypertension a stage in the development of essential hypertension or a diagnostic entity? LancetI, 548 (1945)

    Google Scholar 

  146. Page, I.H.: The renin-angiotensin system. In: Hypertension — A symposium. Bell, E.T. (ed.), Minneapolis, 1950

  147. Palaic, D., Khairallah, P.A.: Inhibition of norepinephrine reuptake by angiotensin in brain. J. Neurochem.15, 1195 (1968)

    Google Scholar 

  148. Panisset, J.C., Biron, P., Beaulnes, A.: Effects of angiotensin on the superior cervical ganglion of the cat. Experientia22, 394 (1966)

    Google Scholar 

  149. Panisset, J.C., Effect of angiotensin on the release of acetylcholine from preganglionic and postganglionic nerve endings. Canad. J. Physiol. Pharmacol.45, 313 (1967)

    Google Scholar 

  150. Pasqualino, A., Bourne, G.H.: Chemical changes in kidneys and adrenals of rats made hypertensive by Goldblatt method. Nature182, 1426 (1958)

    Google Scholar 

  151. Peach, M.J., Bumpus, F.M., Khairallah, P.A.: Release of adrenal catecholamines by angiotensin I. J. Pharmacol. exp. Ther.176, 366 (1971)

    Google Scholar 

  152. Peach, M.J., Chin, A.T.: Stimulation and inhibition of aldosterone biosynthesis in vitro by angiotensin II and analogues. Circ. Res.34, 7 (1974)

    Google Scholar 

  153. Peach, M.J., Bumpus, F.M., Khairallah, P.A.: Inhibition of norepinephrine uptake in hearts by angiotensin II and analogues. J. Pharmacol. exp. Ther.167, 291 (1969)

    Google Scholar 

  154. Phillips, U.I., Felix, D., Hoffmann, W.E., Ganten, D.: Angiotensin-sensitive sites in the brain ventricular system. In: Neuroscience Symposia, Vol. II, Cowan, W., Ferrudelli, J.A. (eds.), p. 308, 1977

  155. Poisner, A.M., Chen, D.S.: Effect of cations and colchicine on renin release from rat kidney. Pharmacologist19, 159 (1975)

    Google Scholar 

  156. Poplawski, A.: The effect of angiotensin II on the platelet aggregation induced by adenosine-diphosphate, epinephrine and thrombin. Experientia (Basel)26, 86 (1969)

    Google Scholar 

  157. Poulsen, K.: Round table discussion on inactive renins. Fifth Scientific Meeting. International Society Hypertension, Paris, June 12–14, 1978

    Google Scholar 

  158. Povolny, K.M., Jung, R.W., Kraft, E., Zimmermann, B.G.: Adrenergic potentiation by angiotensin II in isolated canine cutaneous arteries: Effect of bathing media and calcium. Blood Vessels14, 105 (1977)

    Google Scholar 

  159. Pratt, H.J., Holbrook, M.M., Dale, S.L., Melby, J.C.: The measurement of urinary tetrahydroaldosterone by radioimmunnoassay. J. Steroid Biochem.8, 677 (1977)

    Google Scholar 

  160. Rayyes, S.S., Horton, R.: Effect of angiotensin II on adrenal and pituitary function in man. J. clin. Endocr.82, 539 (1971)

    Google Scholar 

  161. Rosenfeld, S., Bonorris, G., Kraus, L.R., McCullen, A.: Effect of renin and plasma protein loading on albumin catabolism in the isolated perfused kidney. Proc. Soc. exp. Biol.125, 1118 (1967)

    Google Scholar 

  162. Roth, R.H.: Action of angiotensin on adrenergic nerve endings: Enhancement of norepinephrine biosynthesis. Fed. Proc.31, 1358 (1972)

    Google Scholar 

  163. Sakai, K.K., Martes, B.H., George, J., Koestner, A.: Specific angiotensin II receptors in the organ cultured canine supraoptic nucleus cells. Life Sci.14, 1337 (1974)

    Google Scholar 

  164. Saruta, T., Cook, R., Kaplan, N.M.: Adrenocortical steroidogenesis: Studies on the mechanism of action of angiotensin and electrolytes. J. Clin. Invest.,51, 2239 (1972)

    Google Scholar 

  165. Sealey, J.E., Moon, C., Laragh, J.H., Alderman, M.: Plasma prorenin: Cryoactivation and relationship to renin substrate in normal subjects. Am. J. Med.61, 731 (1976)

    Google Scholar 

  166. Shibata, S., Carrier, O., Jr., Frankenheim, J., Darnell, J.R.: Effect of chlorpromazine, dibenamine and phenoxybenzamine on the contractile response of taenia coli to potassium, acetylcholine, angiotensin and barium. J. Pharmacol. exp. Ther.160, 106 (1968)

    Google Scholar 

  167. Simpson, S.A., Tait, A.J., Wettstein, A., Neher, R., v. Euw, J., Reichstein, T.: Isolierung eines neuen kristallisierten Hormons aus Nebennieren mit besonders hoher Wirksamkeit auf den Mineralstoffwechsel. Experientia9, 33 (1953)

    Google Scholar 

  168. Singer, B., Losito, C., Salmon, S.: Aldosterone and corticosterone secretion rates in rats with experimental renal hypertension. Acta Endocr. (Kbh)44, 505 (1963)

    Google Scholar 

  169. Slater, J.D.H., Barbon, B.H., Henderson, H.H., Casper, A.G.T., Bartter, F.C.: Influence of the pituitary and the reninangiotensin system on the secretion of aldosterone, cortisol and corticosterone. J. Clin. Invest.42, 1504 (1963)

    Google Scholar 

  170. Szalay, K.S.: Inhibiting effect of angiotensin on potassium accumulation of adrenal cortex. Biochem. Pharmacol.18, 962 (1969)

    Google Scholar 

  171. Schümann, H.J., Starke, K., Werner, U., Hellerforth, R.: The influence of angiotensin on the uptake of noradrenaline by the isolated heart of the rabbit. J. Pharm. Pharmacol.22, 441 (1970)

    Google Scholar 

  172. Schwartz, J., Bloch, R., Velly, J.: Relations between renin, aldosterone and experimental hypertension in rats. Can. Med. Ass. J.90, 243 (1964)

    Google Scholar 

  173. Schwertschlag, U., Hackenthal, E., Hackenthal, R., Rohs, G.H.: The effects of calcium and calcium-ionophores (X537A and A23187) on renin release in the isolated perfused rat kidney. Clin. Sci. Mol. Med.55, (Suppl. 4) (1978) (in press)

  174. Schwyzer, R., Iselin, B., Kappeler, H., Riniker, B., Rittel, W., Zuber, H.: Synthese hochwirksamer Octapeptide mit der Aminosäuresequenz des Hypertensins II aus Rinderserum. Helv. chim. Acta41, 1287 (1958)

    Google Scholar 

  175. Tewksbury, D.A., Frome, W.L., Dumas, M.L.: Characterization of human angiotensinogen. J. Biol. Chem.253, 3817 (1978)

    Google Scholar 

  176. Thurston, H., Swales, J.D.: Blood pressure response of nephrectomized hypertensive rats to converting enzyme inhibition evidence for persistent vascular renin activity. Clin. Sci. Mol. Med.52, 299 (1977)

    Google Scholar 

  177. Trachewsky, D., Parent, C.: Effect de l'angiotensine II in vitro sur la biosynthèse de l'ARN, les Proteines, l'AMP Cyclique et l'Aldostérone par un septème de suspension cullulaire a partir de la zone glomérulosa des surrénales. L'Union Med. Can.102, 884 (1973)

    Google Scholar 

  178. Türker, R.K., Page, I.H., Khairallah, P.A.: Angiotensin alteration of sodium fluxes in smooth muscle. Arch. Intern. Pharmacodyn.165, 394 (1967)

    Google Scholar 

  179. Ulick, S., Remirez, L.C., New, M.I.: An abnormality in steroid reductive metabolism in a hypertensive syndrome. J. Clin. Endocrinol.44, 799 (1977)

    Google Scholar 

  180. Vecsei, P., Kohl, K.H., Mok, B., Pallai, P., Penke, B., Vielhauer, W., Will, H.: Antibodies against tetrahydro-11-deoxycortisol (THS), tetrahydrocorticosterone (THB), and tetrahydroaldosterone (THALD). V. International Congress of Endocrinology, Hamburg, p. 373, 1976

    Google Scholar 

  181. Vecsei, P., Penke, B., Joumaah, A.: Radioimmunoassay of free aldosterone and of its 18-oxo-glucuronide in human urine. Experientia28, 730 (1972)

    Google Scholar 

  182. Vetter, W., Vetter, H., Siegenthaler, W.: Radioimmunoassay for aldosterone without chromatography. 1. Determination of urinary 18-glucuronide excretion. Acta Endocr. (Kbh)74, 548 (1973)

    Google Scholar 

  183. Villamil, M.F., Nachev, P., Kleeman, C.R.: Effect of prolonged infusion of angiotensin II on ionic composition of the arterial wall. Am. J. Physiol.5, 1281 (1970)

    Google Scholar 

  184. Volicer, L., Hynie, S.: Effect of catecholamines and angiotensin on cyclic AMP in rat aorta and tail artery. Europ. J. Pharmacol.15, 214 (1971)

    Google Scholar 

  185. Weidmann, P., Siegenthaler, W.: Das Renin-Angiotensin-Aldosteron-System bei hypertensiven Zuständen. Dtsch. Med. Wochenschr.43, (1953) (1967)

  186. Weisz, Gláz, E., Purjesz, I., Ritter, L.: Die Aldosteronproduktion der Nebenniere bei experimenteller renaler Hypertonie. Z. Ges. Med.15, 271 (1960)

    Google Scholar 

  187. Weksler, B.B., Marcus, A.J., Jaffe, E.A.: Synthesis of prostaglandin I2 (prostacyclin) by cultured human and bovine endothelial cells. Proc. Natl. Acad. Sci.74, 3922 (1977)

    Google Scholar 

  188. Whorton, A.R., Misono, K., Hollifield, J., Frolich, J.C., Inagami, T., Oates, J.A.: Prostaglandins and renin release. I. Stimulation of renin release from rabbit renal cortical slices by PGI2. Prostaglandins14, 1095 (1977)

    Google Scholar 

  189. Williams, G.H., Braley, L.M., Underwood, R.H.: The regulation of plasma 18-hydroxy-11-deoxycorticosterone in man. J. Clin. Invest.58, 221 (1976)

    Google Scholar 

  190. Williams, G.H., McDonnell, L.M., Raux, M.C., Hollenberg, N.K.: Evidence for different angiotensin II receptors in rat adrenal glomerulosa and rabbit vascular smooth muscle cells. Circ. Res.34, 384 (1974)

    Google Scholar 

  191. Wolff, H.P., Barth, Ch., Distler, A., Düsterdieck, G., Krück, F., Roscher, S., Vecsei, P., Weinges, K.F.: Hypokaliämischer und normokaliämischer primärer Aldosteronismus. Dtsch. med. Wochenschr.94, 760 (1969)

    Google Scholar 

  192. Wolff, H.P., Koczorek, K.R., Buchborn, E.: Aldosteronurie in oedema. In: International Symposium on Aldosterone. Muller, O'Connor (eds.), London: Churchill 1958

    Google Scholar 

  193. Wolff, H.P., Vecsei, P., Krück, F., Roscher, S., Brown, J.J., Düsterdieck, G., Lever, A.F., Robertson, J.I.S.: Psychiatric disturbances leading to potassium depletion sodium raised plasma renin concentration and secondary hyperaldosteronism. Lancet1, 257 (1968)

    Google Scholar 

  194. Woods, J.W., Liddle, G.W., Stant, E.G., Michelakis, A.M., Brill, A.B.: Effect of an adrenal inhibitor in hypertensive patients with suppressed renin. Arch. Intern. Med.123, 366 (1969)

    Google Scholar 

  195. Yankopoulos, N.A., Davis, J.O., Kliman, B., Peterson, R.E., Casper, A.: Evidence that a humoral agent stimulates the adrenal cortex to secrete aldosterone in experimental secondary hyperaldosteronism. J. Clin. Invest.38, 1278 (1959)

    Google Scholar 

  196. Zager, P.G., Brutis, W.J., Luetscher, J.A., Dowdy, A.J., Sood, S.: Increased plasma protein binding and lower metabolic clearance rate of aldosterone in plasma of low cortisol concentration. J. Clin. Endocrinol.42, 207 (1976)

    Google Scholar 

  197. Zimmermann, B.G., Gomer, S.K., Liao, J.C.: Action of angiotensin on vascular adrenergic nerve endings: Facilitation of norepinephrine release. Fed. Proc.31, 1344 (1972)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dept. of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, D-6900, Heidelberg, Federal Republic of Germany

    P. Vecsei M.D.

Authors
  1. P. Vecsei M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Hackenthal
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. Ganten
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vecsei, P., Hackenthal, E. & Ganten, D. The renin-angiotensin-aldosterone system. Klin Wochenschr 56 (Suppl 1), 5–21 (1978). https://doi.org/10.1007/BF01477448

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01477448

Keywords

Search

Navigation