Zusammenfassung
Spezifische IgG-Antikörper gegen Bienengift und Bienengift-Bestandteile wurden im Serum von 23 Imkern bestimmt. Die höchsten Titer wurden gegen das Gesamt-Bienengift gefunden, jeweils geringere gegen Phospholipase A, Melittin, MCD-Peptid und Apamin. Bei Messung der spezifischen IgG-Antikörper der Subklassen 1–4 gegen Gesamt-Bienengift und Phospholipase A wurden die höchsten Titer in den Subklassen 4 und 2, die niedrigsten in der Subklasse 1 gefunden. Nach 5 Monaten ohne Bienenstiche wiesen alle untersuchten Imker einen Antikörper-Abfall auf. Die klinisch stärkste Reaktion auf Bienenstiche zeigten Imker mit den niedrigsten spezifischen IgG-Spiegeln. Diese Untersuchungen zeigen, daß spezifische IgG-Antikörper eine wichtige Rolle bei der Verhinderung von allergischen Symptomen nach Bienenstich spielen.
Summary
Specific IgE antibodies against bee venom and its components were studied in 23 bee-keepers. The highest IgG serum levels were observed for whole bee venom followed by phospholipase A. The serum levels of specific IgG antibodies against melittin and MCD-peptide were lower, the lowest serum levels being observed for apamin. After a 5 month absence from bee-keeping a fall in the serum levels of IgG antibodies was observed in all the bee-keepers studied. The investigation of the IgG subclass antibodies 1–4 against bee venom and phospholipase A demonstrated the highest serum levels for IgG 4 and IgG 2, the lowest levels were observed for IgG 1. The lowest IgG serum levels were associated with the least effective protection to bee stings. These findings support the concept that specific IgG antibodies prevent the development of allergic symptoms after bee sting.
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This study was supported by Deutsche Forschungsgemeinschaft, grant Ur 12/2-3
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Urbanek, R., Forster, J., Ziupa, J. et al. Immunological studies on bee-keepers: Specific IgG and subclass typing IgG against bee venom and bee venom components. Klin Wochenschr 58, 1257–1260 (1980). https://doi.org/10.1007/BF01478932
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DOI: https://doi.org/10.1007/BF01478932