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Renin release after furosemide and ethacrynic acid in man

Evidence for neural reflex control mechanisms

Reninfreisetzung nach Furosemid und Ethacrynsäure

Hinweise auf neurale Reflexmechanismen

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Summary

The mechanisms of renin release after furosemide (F) and ethacrynic acid (EA) in man were examined.

We evaluated whether acute volume shifts within the low pressure system after F induce renin release via neural pathways.

Immersion in a water-bath or beta-blockade reduced the increase of plasma renin concentration after F but not after EA.

It is concluded that acute renin release after F but not after EA in man is partially due to neurally mediated reflexes originating from volume receptors in the cardiopulmonary area.

Zusammenfassung

Es wurden die Mechanismen der Reninfreisetzung nach Furosemid und Ethacrynsäure beim Menschen untersucht. Geprüft wurde die Hypothese, ob akute Volumenverschiebungen innerhalb des Niederdrucksystems nach Furosemid zu einer neural vermittelten Reninstimulation führen. Sowohl Immersion in einem Wasserbad als auch Betablokkade reduzierte den Reninanstieg nach Furosemid nicht jedoch nach Ethacrynsäure. Es wird geschlossen, daß die akute Reninfreisetzung nach Furosemid, nicht jedoch nach Ethacrynsäure teilweise auf neuralen Reflexmechanismen — ausgehend von Volumenrezeptoren des Niederdrucksystems — beruht.

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Authors and Affiliations

  1. Department of Internal Medicine II, University of Cologne, Germany

    J. H. Fischer

  2. Institute of Experimental Medicine, University of Cologne, Germany

    W. Hummerich, A. Konrads, D. K. Krause, J. H. Fischer & W. Kaufmann

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  1. W. Hummerich
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  2. A. Konrads
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  3. D. K. Krause
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  4. J. H. Fischer
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  5. W. Kaufmann
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Hummerich, W., Konrads, A., Krause, D.K. et al. Renin release after furosemide and ethacrynic acid in man. Klin Wochenschr 59, 791–795 (1981). https://doi.org/10.1007/BF01724685

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  • DOI: https://doi.org/10.1007/BF01724685

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