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Changes in gallbladder motor function during the female cycle — a risk factor leading to gallstone formation?

Veränderungen der Gallenblasenmotorik während des weiblichen Zyklus — Risikofaktor für die Gallensteinbildung?

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Summary

The gallbladder volume of eight women with stable cycles was determined by sonography. Furthermore, gallbladder contraction — following an orally administered fatty meal and the spontaneous refilling of the empty gallbladder — was quantitatively examined. The formula of a rotation ellipsoid, which has been proven to be adequately accurate in in vitro studies, was used for calculating the gallbladder volume. In the gestagen phase (21st or 22nd day) the intraindividual studies showed greater fasting volumes, higher residual volumes after contraction, slower gallbladder emptying, and retarded refilling of the empty gallbladder as compared to the estrogen phase (12th or 13th day). The hormonally modified contraction behavior and the differing course of gallbladder filling may play a major role in the pathogenesis of gallstone formation.

Zusammenfassung

Bei 8 Frauen mit stabilem Zyklus wurden mittels Sonographie das Gallenblasenvolumen bestimmt und in der Progesteron- sowie der Östrogenphase des Zyklus die Gallenblasenkontraktion nach oraler Reizmahlzeit und die spontane Wiederauffüllung der entleerten Gallenblase quantitativ untersucht. Zur Volumenberechnung wurde die Formel eines Drehellipsoids verwandt, die sich im Modellversuch als hinreichend exakt erwiesen hatte. Die intraindividuellen Vergleichsuntersuchungen zeigten in der Progesteronphase (21. oder 22. Tag) gegenüber der östrogenphase (12. oder 13. Tag) statistisch gesicherte größere Nüchternvolumina, höhere Residualvolumina nach Kontraktion und eine langsamere Gallenblasenentleerung sowie eine verzögerte Wiederauffüllung der entleerten Gallenblase. Dem hormonal modifizierten Kontraktionsverhalten und der unterschiedlich ablaufenden Gallenblasenfüllung könnte im Rahmen der Gallensteinentstehung eine wesentliche Bedeutung zukommen.

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  1. II. Medizinische Klinik und Poliklinik der Universität Mainz, Germany

    B. Braun & H. H. Dormeyer

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  1. B. Braun
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Braun, B., Dormeyer, H.H. Changes in gallbladder motor function during the female cycle — a risk factor leading to gallstone formation?. Klin Wochenschr 60, 1357–1362 (1982). https://doi.org/10.1007/BF01716215

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  • DOI: https://doi.org/10.1007/BF01716215

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