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Deposition of polymeric IgA1 in idiopathic mesangial IgA-glomerulonephritis

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Summary

IgA deposits in kidney and skin biopsies from patients with idiopathic mesangial IgA-glomerulonephritis were characterized with immunofluorescence microscopy using monoclonal antibodies against the IgA subclasses IgA1 and IgA2. IgA1 was the major constituent in all biopsy specimens. Double immunofluorescence microscopy showed that IgA deposits were constantly associated with J-chain. Secretory component was never found in the deposited material. In vitro fixation of free secretory component, however, was observed in some biopsies. These findings indicate that most if not all of the deposited IgA in patients with idiopathic IgA-glomerulonephritis is polymeric in nature.

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References

  1. André C, Berthoux FC, André F, Gillon J, Genin C, Sabatier JCh (1980) Prevalence of IgA2 deposits in IgA nephropathics: a clue to their pathogenesis. N Engl J Med 303:1343–1346

    PubMed  Google Scholar 

  2. Baart de la Faille-Kuyper EH, Kater L, Kuijten RH, Kooiker CJ, Wagenaar SS, van der Zouwen P, Dorhout Mees EJ (1976) Occurrence of vascular IgA deposits in clinically normal skin of patients with renal disease. Kidney Int 9:424–429

    PubMed  Google Scholar 

  3. Bene MC, Faure G, Duheille J (1982) IgA-nephropathy: characterization of the polymeric nature of mesangial deposits by in vitro binding of free secretory component. Clin Exp Immunol 47:527–534

    PubMed  Google Scholar 

  4. Berger J, Yaneva H, Crosnier J (1980) La glomérulonéphrite à dépôts mésangiaux d'IgA: une cause fréquente d'insuffisance rénale terminale. Nouv Press Med 9:219–221

    Google Scholar 

  5. Brandtzaeg P (1973) Two types of immunocytes in man. Nature 243:142–143

    Google Scholar 

  6. Brandtzaeg P (1974) Presence of J-chain in human immunocytes containing various immunoglobulin classes. Nature 252:418–419

    PubMed  Google Scholar 

  7. Brandtzaeg P (1976) Studies on J-chain and binding site for secretory component in circulating human B cells. I. The surface membrane. Clin Exp Immunol 25:50–58

    PubMed  Google Scholar 

  8. Brandtzaeg P (1978) Polymeric IgA is complexed with secretory component (SC) on the surface of human intestinal epithelial cells. Scand J Immunol 8:39–52

    PubMed  Google Scholar 

  9. Chatenoud L, Bach MA (1981) Abnormalities of T-cell subsets in glomerulonephritis and systemic lupus erythematosus. Kidney Int 20:267–274

    PubMed  Google Scholar 

  10. Clarkson AR, Seymour AE, Thompson AJ, Haynes WDG, Chan YL, Jackson B (1978) IgA nephropathy: a syndrome of uniform morphology, diverse clinical features and uncertain prognosis. Clin Nephrol 8:459–471

    Google Scholar 

  11. Conley ME, Cooper MD, Michael AF (1980) Selective deposition of immunoglobulin A1 in immunoglobulin A nephropathy, anaphylactoid purpura nephritis and systemic lupus erythematosus. J Clin Invest 66:1432–1436

    PubMed  Google Scholar 

  12. Conley ME, Kearney JF (1980) Hybridoma antibodies specific for human IgA subclasses. (Abstr) Fed Proc 39:927

    Google Scholar 

  13. Conley ME, Kearney JF, Lawton III AR, Cooper MD (1980) Differentiation of human B cells expressing the IgA subclasses as demonstrated by monoclonal antibodies J Immunol 125:2311–2316

    PubMed  Google Scholar 

  14. Coppo R, De Marchi M, Aprato A, Roccatello D, Messina M, Segolini G, Camussi G, Alloato S, Giacchino F, Carbonara AO, Cercellone A, Piccoli G (1980) A new test for IgA-containing immune complexes or aggregated IgA: its application to Berger and Schönlein-Hennoch nephritis. Proc Eur Dial Transplant Assoc 17:667–672

    PubMed  Google Scholar 

  15. Dobrin RS, Knudson FE, Michael AF (1975) The secretory immune system and renal disease. Clin Exp Immunol 21:318–328

    PubMed  Google Scholar 

  16. Donini U, Casanova S, Zini N, Zucchelli P (1982) The presence of J chain in mesangial immune deposits of IgA nephropathy. Proc Eur Dial Transpl Assoc 19:655–662

    Google Scholar 

  17. Droz D (1976) Natural history of primary glomerulonephritis with mesangial deposits of IgA. Contr Nephrol 2:150–157

    Google Scholar 

  18. Egido J, Sancho J, Mampaso F, Lopez-Trascasa M, Sanchez-Crespo M, Blasco R, Hernando L (1980) A possible common pathogenesis of the mesangial IgA glomerulonephritis in patients with Berger's disease and Schönlein Henoch syndrome. Proc Eur Dial Transpl Assoc 17:660–666

    Google Scholar 

  19. Egido J, Blasco R, Sancho J, Lozano L, Sanchez-Crespo M, Hernando L (1982) Increased rates of polymeric IgA synthesis by circulating lymphoid cells in IgA mesangial glomerulonephritis. Clin Exp Immunol 47:309–316

    PubMed  Google Scholar 

  20. Kutteh WH, Koopman WJ, Conley ME, Egan ML, Mestecky J (1980) Production of predominantly polymeric IgA by human peripheral blood lymphocytes stimulated in vitro with mitogens. J Exp Med 152:1424–1429

    PubMed  Google Scholar 

  21. Lopez-Trascasa M, Egido J, Sancho J, Hernando L (1980) IgA glomerulonephritis (Berger's disease): evidence of high serum levels of polymeric IgA. Clin Exp Immunol 42:247–254

    PubMed  Google Scholar 

  22. Mach J-P (1970) In vitro combination of human and bovine free secretory component with IgA of various species. Nature 228:1278–1282

    PubMed  Google Scholar 

  23. Mustonen J, Pasternack A, Helin H, Rilva A, Penttinen K, Wagner O, Harmoinen A (1981) Circulating immune complexes, the concentration of serum IgA and the distribution of HLA antigens in IgA nephropathy. Nephron 29:170–175

    PubMed  Google Scholar 

  24. Nomoto Y, Sakai H, Arimori S (1979) Increase of IgA-bearing lymphocytes in peripheral blood from patients with IgA nephropathy. Am J Clin Pathol 71:158–160

    PubMed  Google Scholar 

  25. Rambausek M, Seelig HP, Andrassy K, Waldherr R, Lenhard V, Ritz E (1982) Clinical and serological features of mesangial IgA glomerulonephritis. Proc Eur Dial Transplant Assoc 19:663–668

    Google Scholar 

  26. Rifai A, Small PA, Teague OP, Ayoub EM (1979) Experimental IgA nephropathy. J Exp Med 150:1161–1173

    PubMed  Google Scholar 

  27. Sakai H, Nomoto Y, Arimori S (1979) Decrease of IgA-specific suppressor T cell activity in patients with IgA nephropathy. Clin Exp Immunol 38:243–248

    PubMed  Google Scholar 

  28. Sinniah R, Javier AR, Ku G (1981) The pathology of mesangial IgA nephritis with clinical correlation. Histopathology 5:469–490

    PubMed  Google Scholar 

  29. Stachura I, Singh G, Whiteside TL (1981) Immune abnormalities in IgA nephropathy (Berger's disease). Clin Immunopathol 20:373–388

    Google Scholar 

  30. Thompson AJ, Chan Y-L, Woodroffe AJ, Clarkson AR, Seymour AE (1980) Vascular IgA deposits in clinically normal skin of patients with renal disease. Pathology 12:407–413

    PubMed  Google Scholar 

  31. Tomasi ThB (1976) The immune system of secretions. Prentice-Hall, Englewood Cliffs NJ

    Google Scholar 

  32. Tomino Y, Endoh M, Nomoto Y, Sakai H (1981) Immuno-globulin A1 in IgA nephropathy. N Engl J Med 305:1159–1160

    PubMed  Google Scholar 

  33. Whitworth JA, Leibowitz S, Kennedy MC, Cameron JS, Chantler C (1976) IgA and glomerular disease. Clin Nephrol 5:33–36

    PubMed  Google Scholar 

  34. Woodroffe AJ, Gormly AA, McKenzie PE, Wootton AM, Thompson AJ, Seymour AE, Clarkson AR (1980) Immunologic studies in IgA nephropathy. Kidney Int 18:366–374

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, University of Heidelberg, Germany

    R. Waldherr

  2. Institute for Immunology and Serology, Karlsruhe

    H. P. Seelig

  3. Pathologisches Institut der Universität Heidelberg, Im Neuenheimer Feld 220/221, Postfach 104340, D-6900, Heidelberg 1, Germany

    M. Rambausek, K. Andrassy & E. Ritz

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  1. R. Waldherr
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  2. H. P. Seelig
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  3. M. Rambausek
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  4. K. Andrassy
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  5. E. Ritz
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Waldherr, R., Seelig, H.P., Rambausek, M. et al. Deposition of polymeric IgA1 in idiopathic mesangial IgA-glomerulonephritis. Klin Wochenschr 61, 911–915 (1983). https://doi.org/10.1007/BF01537531

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  • DOI: https://doi.org/10.1007/BF01537531

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