Summary
The use of mathematical models in haematology is shown by some examples concerning stem cell kinetics, erythropoiesis and thrombopoiesis. At first, model assumptions are formulated which include the biological knowledge and some regulatory hypotheses. Then, the reaction of the model on stimulation and suppression is calculated. Finally, by comparison with experimental or clincal data one can evaluate how far the model assumptions are sufficient to understand the measurements. Thus one can exclude wrong hypotheses and identify the important regulatory influences.
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Herrn Prof. Dr. R. Gross zum 1.10. 1983 gewidmet
Mit Unterstützung der Deutschen Forschungsgemeinschaft
und der Stiftung Volkswagenwerk
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Wichmann, H.E., Loeffler, M., Herkenrath, P. et al. Mathematische Modelle in der Hämatologie. Klin Wochenschr 61, 935–940 (1983). https://doi.org/10.1007/BF01550265
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DOI: https://doi.org/10.1007/BF01550265