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Anti-HBc IgM bei akuter und chronischer Hepatitis-B-Virus-Infektion

Determination of anti-hepatitis B core immunoglobin M in acute and chronic hepatitis B virus infections

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Summary

Hepatitis B core antigen (HBcAg) synthesized in E. coli was used for determination of immunoglobulin M class-specific antibodies against HBcAg. It was found that 98% of cases with acute hepatitis B surface antigen (HBsAg) positive hepatitis type B were anti-HBc immunoglobulin M (IgM) positive. Atypical hepatitis B was detected in 33% of anti-HBc-positive HBsAg-negative cases with acute hepatitis. Anti-HBc IgM was positive for 6 months in acute resolving hepatitis type B, whereas cases resulting in chronic hepatitis B remained anti-HBc IgM-positive for up to 900 days. Chronic HBsAg carriers with severe liver disease had anti-HBc IgM more often than individuals with minor liver damage; 83% of HBsAg-positive liver cirrhoses, 63% of chronic aggressive hepatitis, 50% of HBsAg-positive liver carcinoma, but only 17% of chronic persistent hepatitis or 7% of healthy blood donors were anti-HBc IgM-positive. Determination of anti-HBc IgM is useful in detecting atypical hepatitis B virus infections without HBsAg in serum and, with some restrictions, in discriminating acute and chronic hepatitis type B.

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Authors and Affiliations

  1. Medizinische Klinik, Abteilung 1.1.4. — Gastroenterologie, Abteilung 9.1.5. — Medizinische Virologie und Institut für Mikrobiologie, Universität Heidelberg, Germany

    K. Gmelin, L. Theilmann, G. Hasche, H. Will, P. Czygan, H. W. Doerr & B. Kommerell

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  1. K. Gmelin
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  2. L. Theilmann
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  3. G. Hasche
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  4. H. Will
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  5. P. Czygan
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  6. H. W. Doerr
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  7. B. Kommerell
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Gmelin, K., Theilmann, L., Hasche, G. et al. Anti-HBc IgM bei akuter und chronischer Hepatitis-B-Virus-Infektion. Klin Wochenschr 62, 837–842 (1984). https://doi.org/10.1007/BF01711864

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  • DOI: https://doi.org/10.1007/BF01711864

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