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Bone mineral content after renal transplantation

Placebo-controlled prospective study with 1,25-dihydroxy vitamin D3

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Summary

Forearm bone mineral content (BMC), as evaluated by photonabsorption densitometry, was measured in 28 cadaver kidney donor recipients who entered the study 8 weeks postoperatively and were followed up for 18 months. BMC decreased signifiantly (p<0.05) but marginally in placebo-treated patients (n=14) (initial BMC 1.09±0.25 g/cm; final BMC 1.05±0.24). Fourteen patients were prophylactically given 1,25(OH)2vitamin D3 in a dose which avoided hypercalcemia and hypercalciuria (∼0.25 µg/day); under 1,25(OH)2 vitamin D3 prophylaxis a significant decrease of forearm BMC was observed no longer (initial BMC 0.94±0.21 g/cm; final BMC 0.95±0.21), but the difference between placebo and 1,25(OH)2 vitamin D3 narrowly missed statistical significance (p=0.066).

It is concluded that the decrease of forearm BMC is negligible in transplant recipients with low steroid regimens. The data suggest a trend for prophylaxis with 1,25(OH)2 vitamin D3 to slightly ameliorate forearm (cortical) BMC loss.

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Authors and Affiliations

  1. Depts. of Internal Medicine, Urology, and Neurology, University of Heidelberg, Germany

    E. Neubauer, N. Neubauer,  E. Ritz MD, K. Dreikorn & K. -H. Krause

Authors
  1. E. Neubauer
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  2. N. Neubauer
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  3. E. Ritz MD
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  4. K. Dreikorn
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  5. K. -H. Krause
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Presented in abstract form at the 15th Annual Meeting of the Gesellschaft für Nephrologie in Basel, September 12–15, 1982

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Neubauer, E., Neubauer, N., Ritz, E. et al. Bone mineral content after renal transplantation. Klin Wochenschr 62, 93–96 (1984). https://doi.org/10.1007/BF01769669

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  • DOI: https://doi.org/10.1007/BF01769669

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