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Lymphadenopathy and antibodies to HTLV-III in homosexual men

Clinical, laboratory and epidemiological features

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Summary

The study provides information on the epidemiology of HTLV-III infection and the lymphadenopathy syndrome (LAP) in 374 German homosexual men. Sexual contacts in the USA and rectal enemas before receptive anal intercourse are the main risk factors associated with virus transmission. HTLV-III seropositivity is significantly correlated with LAP. Prominent clinical signs are infreqquent. Immunological and haematological abnormalities are prevalent, and the retrovirus infection is frequently associated with serological markers of other viruses (hepatitis B, herpes group viruses). Lymphadenopathy as a manifestation of HTLV-III infection is discussed within the context of AIDS-related disorders.

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Abbreviations

AIDS:

Acquired Immunodeficiency Syndrome

CMV:

Cytomegalovirus

EBV:

Epstein-Barr virus

HBV:

Hepatitis B virus

HTLV-III:

Human leukaemia retrovirus type III

LAP:

Lymphadenopathy

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Author information

Authors and Affiliations

  1. Landesinstitut für Tropenmedizin, Berlin

    U. Bienzle & K. Zwingenberger

  2. Institut für Medizinische Statistik und Dokumentation, Universität Erlangen, Germany

    I. Guggenmoos-Holzmann & K. Ritter

  3. Institut für Medizinische Mikrobiologie, Universität Göttingen, Germany

    R. Thommsen & A. Uy

  4. Deutsches Primatenzentrum, Göttingen

    H. Bayer, J. Schneider & G. Hunsmann

  5. Institut für Medizinische Mikrobiologie, Freie Universität Berlin, Germany

    C. H. Coester

  6. Institut für Klinische Immunologie und Rheumatologie, Universität Erlangen, Germany

    J. R. Kalden

Authors
  1. U. Bienzle
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  2. I. Guggenmoos-Holzmann
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  3. K. Zwingenberger
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  4. R. Thommsen
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  5. K. Ritter
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  6. A. Uy
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  7. H. Bayer
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  8. J. Schneider
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  9. G. Hunsmann
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  10. C. H. Coester
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  11. J. R. Kalden
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Bienzle, U., Guggenmoos-Holzmann, I., Zwingenberger, K. et al. Lymphadenopathy and antibodies to HTLV-III in homosexual men. Klin Wochenschr 63, 597–602 (1985). https://doi.org/10.1007/BF01733012

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  • DOI: https://doi.org/10.1007/BF01733012

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