Summary
Oral contraception as well as cigarette smoking influence haemostasis. The simulataneous effect of both on blood coagulation and fibrinolysis was studied in nine female smokers. While continuing oral contraception after a 4-week abstinence from smoking the concentration of fibrinogen, antithrombin III and alpha1-Antitrypsin decreased (P<0.01 orP<0.04) and of plasminogen increased (P<0.03). The other coagulation parameters remained unchanged. Although all determinations of these parameters were in the normal range, the observed trends were statistically significant. The concentrations of the fibrinopeptide A and B 15–42 did not differ. It is concluded that the observed alteration is caused by cessation from cigarette smoking.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Beral V (1976) Cardiovascular-disease mortality trends and oral contraceptive use in young women. Lancet 2:13–16
Blombäck B, Hessel B, Therkildsen L, Hogg D (1978) A two-step fibrinogen fibrin transition in blood coagulation. Nature 275:501–512
Eckhardt T, Nossel HL, Hurlet-Jensen A, La Gamma KS, Owen J, Auerbach M (1981) Measurement of desarginine fibrinopeptide B in human blood. J Clin Invest 67:809–816
La Gamma KS, Nossel HL (1978) The stability of fibrinopeptide B immunoreactivity in blood. Thromb Res 12:447–454
Gerrits WBJ, Flier TN, van der Meer J (1974) Fibrinopeptide A immunoreactivity in human plasma. Thromb Res 5:197–207
Hammond EC, Garfinkel L, Seidmann H (1976) “Tar” and nicotine content of cigarette smoke in relation to death rates. Environ Res 12:1102–1103
Harenberg J, Walter E, Weber E (1978) Die intraindividuelle Streuung der fibrinolytischen Aktivität bei Probanden. Klin Wochenschr 56:445–448
Harenberg J, Hepp G, Schmidt-Gayk H (1979) Fibrinopeptide A in human plasma; evalution of a new radioimmunoassay technique on microtiter-plates. Throm Res 15:513–522
Harenberg J, Stehle G, Schmidt-Gayk H, Zimmermann R (1981a) Fibrinopeptide A (FPA) radioimmunoassay; influence of the affinity of the second antibody for FPA antiserum. Thromb Res 21:531–532
Harenberg J, Walter E, Spohr U, Mörl H, Zimmermann R, Weber E (1981b) Is the diurnal rhythm of fibrinolytic activity and platelet aggregation in man influenced by cigarette smoking? Angiocardiology 3:232–236
Harenberg J, Baumgärtner A, Fritze D, Zimmermann R (1982) Hypercoagulability after immunotherapy with corynebacterium parvum in man. Blut 44:241–247
Harenberg J, Stehle G, Waibel St, Hermann HJ, Eisenhut M, Zimmermann R (1983) Disposition of human fibrinopeptide A in normal and nephrectomized rabbits. Thromb Res 32:1–13
Hengen N, Hengen M (1978) Gas-liquid chromatographic determination of nicotine and cotinine in plasma. Clin Chem 24:50–55
Kannel WB (1978) American Heart Association report of ad hoc Committee on cigarette smoking and cardiovascular diseases. Circulation 57:404–409
Kudryk B, Robinson D, Netre C, Hessel B, Blombäck M, Blombäck B (1982) Measurement in human blood of fibrinogen/fibrin fragments containing the Bβ 15–42 sequence. Thromb Res 25:277–291
Lane DA, Siodlak M, Thompson E, Allen-Mersh TG (1982) Clearence of human desaminotyrosyl fibrinopeptide A from the rat circulation: Role of kidney and proteolytic enzymes. Throm Res 26:73–82
Mann JI, Vessey MP, Thorogood M et al. (1975) Myocardial infarction in young women with special reference to oral contraceptive practice. Br Med 2:241–245
Nossel HL, Yudelman I, Canfield RE, Butler VP, Spanondis K, Wilner GD, Qureshi GD (1974) Measurement of fibrinopeptide A in human blood. J Clin Invest 54:43–52
Nossel HL, Wasser J, Kaplan KL, La Gamma KS, Yudelman I, Canfield RE (1979) Sequence of fibrinogen proteolysis and platelet release after intrauterine infusion of hypertonic saline. J Clin Invest 64:1371–1380
Ogston D, Bennett NB, Ogston CM (1970) The influence of cigarette smoking on the plasma fibrinogen concentration. Atherosclerosis 11:349–352
Sagar S, Stamatakis JD, Thomas DP, Kakkar VV (1976) Oral contraceptives, antithrombin III activity, and postoperative deep-vein thrombosis. Lancet 1:509–511
Author information
Authors and Affiliations
Additional information
This work has been supported by grants from Forschungsrat Rauchen und Gesundheit
Rights and permissions
About this article
Cite this article
Harenberg, J., Staiger, C., de Vries, J.X. et al. The effects of a combination of cigarette smoking and oral contraception on coagulation and fibrinolysis in human females. Klin Wochenschr 63, 221–224 (1985). https://doi.org/10.1007/BF01731173
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01731173