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Einfluß von PIND-AVI auf unterschiedliche Ausgangsverhältnisse von Helfer- und Suppressor-T-Lymphozyten

The influence of PIND-AVI on different helper/suppressor T-lymphocyte ratios

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Summary

The immunomodulating effect of a new heterologous antigen (PIND-AVI) on helper (inducer) and suppressor T cells was investigated. Primarily decreased T4 values\(\left( { \leqslant \overline X _{T4} - 2S.D.} \right)\) increased after treatment with PIND (P<0.005, using Student'st-test;n=15). Primarily increased T8 values (\( \geqslant \overline X _{T8} + 2S.D.\); obtained for normal persons) decreased after therapy (P<0.001;n=10). An increase of T4/T8 ratio (P<0.005 and <0.001) to normal values was observed in both cases. T4 and T8 values within the mean ±2 S.D. were not influenced significantly (n=13). In spite of different primary values, the amount of lymphocytes/mm3 was not significantly influenced. It appears advisable to check the results of treatment continuously every few weeks.

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Abbreviations

PIND-AVI:

Paramunitätsinducer auf der Antigenbasis eines aviären Poxvirus

T4=TH :

Helfer/Inducer-T-Lymphozyt

T8=TS/C :

Suppressor/Zytotoxischer-T-Lymphozyt

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Authors and Affiliations

  1. Institut für Mikrobiologie und Hygiene der Technischen Universität München, Germany

    Th. Schleich & H. Stickl

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  1. Th. Schleich
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  2. H. Stickl
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Schleich, T., Stickl, H. Einfluß von PIND-AVI auf unterschiedliche Ausgangsverhältnisse von Helfer- und Suppressor-T-Lymphozyten. Klin Wochenschr 64, 1192–1197 (1986). https://doi.org/10.1007/BF01728460

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  • DOI: https://doi.org/10.1007/BF01728460

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