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Zur Wirksamkeit von IFN-γ und IFN-α bei der Haarzellenleukämie

Efficacy of gamma- and alpha-interferon in hairy-cell leukemia

  • Symposium Haarzelleukämie und ihre therapeutische Beeinflußbarkeit durch Interferone Erster Hannoverscher Interferon-Workshop, 1. Februar 1986
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Summary

Six patients with hairy-cell leukemia were treated with gamma-(IFN-γ) and alpha-(IFN-α-2b) interferon; 3–35 months following splenectomy, treatment was started with 4 × 106 U/m2 IFN-γ sc (iv) every second day for 9–35 weeks. Although the white blood cell counts decreased during therapy from 4.1–49 × 109/1 to 1.5–43 × 109/1, no hematological or clinical improvement was obtained. Subsequently (interval 0–13 weeks), IFN-α-2b was given at an initial dose of 4 × 106 U/m2 sc every second day to all patients. After a treatment period corresponding to that of IFN-γ administration, a significant hematological improvement was observed in five patients (one early death due to pulmonary embolism). At the last follow-up (9–14 months after start of treatment; maintenance therapy, 1 × 106 U every second day), these patients exhibited normal peripheral blood cell counts, and in bone marrow biopsy specimens a marked decrease of hairy cells was seen (1 CR, 3 PR, 1 MR). Adverse reactions including fever, headache, nausea, dryness of the mouth, myalgia, and fatigue did not significantly differ between the two interferon preparations. Whereas IFN-γ is unlikely to have any significant impact on the course of hairy cell leukemia, IFN-α-2b does result in improvement of hematological values and well-being in almost all patients.

Zusammenfassung

6 Patienten mit einer Haarzellenleukämie wurden 3–35 Monate nach Splenektomie mit IFN-γ (4 × 106 E/m2/2. Tag sc) behandelt. Während einer Therapiedauer von 9–35 Wochen konnte bei keinem Patienten eine signifikante klinische oder hämatologische Befundbesserung erzielt werden. Nach einem therapiefreien Intervall von 0–13 Wochen erhielten alle Patienten IFN-α-2b (zunächst 4 × 106 E/m2/2. Tag, Erhaltungstherapie 1 × 106 E/2. Tag). Zum Zeitpunkt der Beendigung der jeweiligen IFN-α-2b-Gabe war bei 5 von 6 Patienten (1 Patient mit postthrombotischem Syndrom verstarb an einer Lungenembolie) eine deutliche Befundbesserung eingetreten. Nach einer Beobachtungszeit von jetzt 9–14 Monaten konnten 1 CR, 3 PR und 1 MR induziert werden. Die Nebenwirkungen beider Interferon-Präparationen unterschieden sich nicht signifikant.

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Authors and Affiliations

  1. Innere Universitätsklinik und Poliklinik (Tumorforschung), Westdeutsches Tumorzentrum, Essen

    N. Niederle, C. Doberauer, O. Kloke, K. Höffken & C. G. Schmidt

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  1. N. Niederle
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  2. C. Doberauer
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  3. O. Kloke
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  4. K. Höffken
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  5. C. G. Schmidt
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Niederle, N., Doberauer, C., Kloke, O. et al. Zur Wirksamkeit von IFN-γ und IFN-α bei der Haarzellenleukämie. Klin Wochenschr 65, 706–712 (1987). https://doi.org/10.1007/BF01875510

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