Skip to main content
SpringerLink
Log in

Relapsing poly(peri)chondritis associated with fibrosing alveolar disease and antibodies to pneumocytes type II and clara cells

  • Kasuistik
  • Published:
Klinische Wochenschrift Aims and scope Submit manuscript

Summary

A 62-year-old man with histological confirmed relapsing polychondritis showed chondritis of ears and nose, arthritis, keratitis and a hemolytic anemia. The bronchoalveolar lavage, computed tomography of the thorax and pulmonary function tests disclosed findings compatible with fibrosing alveolar disease. IgG antibodies to alveolar pneumocytes type II and bronchiolar Clara cells were detected by indirect immunofluorescense of human lung tissue. To our knowledge this is the first report of fibrosing alveolar disease in relapsing polychondritis and detection of antibodies to human pneumocytes type II and Clara cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Baumgartner U, Schölmerich J, Becher S, Costabel U (1987) Detection of antibodies in serum of patients with idiopathic pulmonary fibrosis against isolated rat alveolar type II cells. Respiration 52:122–128

    Article  CAS  PubMed  Google Scholar 

  2. Burgeson RE, Hollister DW (1979) Collagen heterogeneity in human cartilage: identification of several new collagen chains. Biochem biophysica Res Com 87:1124–1131

    Article  CAS  Google Scholar 

  3. Case Recorts of the Massachusetts General Hospital, Case 51-1982 (1982) N Engl J Med 307:1631–1639

    Google Scholar 

  4. Case Records of the Massachusetts General Hospital, Case 50-1985 (1985) N Engl J Med 313:1530–1537

    Google Scholar 

  5. Cohen PR, Rapini RP (1986) Relapsing polychondritis. Int J Dermatology 25:280–285

    Article  CAS  Google Scholar 

  6. Crystal RG, Bitterman PB, Rennard SI, Hance AJ, Keogh BA (1984) Interstitial lung disease of unknown cause. N Engl J Med 310:154–166

    Article  CAS  PubMed  Google Scholar 

  7. Chapman JR, Charles PJ, Venables JW, Thompson PJW, Haslam PL, Maini RN, Turner-Warwick MEH (1984) Definition and clinical relevance of antibodies to nuclear ribonucleoprotein and other nuclear antigens in patients with cryptogenetic fibrosing alveolitis. Am Rev Respir Dis 130:439–443

    CAS  PubMed  Google Scholar 

  8. Damiani JM, Levine HL (1979) Relapsing polychondritis-report of ten cases. Laryngoscope 89:929–946

    Article  CAS  PubMed  Google Scholar 

  9. Daniele RP, Elias JA, Epstein PE, Rossman MD (1985) Bronchoalveolar lavage. Role in the pathogenesis, diagnosis and management of interstitial lung disease. Ann Int Med 102:93–108

    Article  CAS  PubMed  Google Scholar 

  10. Estes SA (1983) Relapsing polychondritis. Cutis 32:470–476

    Google Scholar 

  11. Foidart JM, Abe S, Martin GR, Zizic TM, Barnett EV, Lawley TJ, Katz SI (1978) Antibodies to type II collagen in relapsing polychondritis. N Engl J Med 299:1203–1207

    Article  CAS  PubMed  Google Scholar 

  12. Gibson GJ, Davis P (1974) Respiratory complications of relapsing polychondritis. Thorax 29:726–731

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Gollhausen R, Krieg T, Gollmitzer W, Landthaler M (1988) Polychondritis recidivans et atrophicans. Hautarzt 39:240–242

    CAS  PubMed  Google Scholar 

  14. Hammar SP, Winterbauer RH, Bockus D, Remington F, Friedman S (1985) Idiopathic fibrosing alveolitis: A review with emphasis on ultrastructural and immunohistochemical features. Ultrastruct Pathology 9:345–354

    Article  CAS  Google Scholar 

  15. Hunningshake GW, Fauci AS (1979) Pulmonary involvement in collagen vascular diseases. Am Rev Respir Dis 119:471–503

    Google Scholar 

  16. Isaak BL, Liesegang TJ, Michet CJ (1986) Ocular and systemic findings in relapsing polychondritis. Ophthalmology 93:681–689

    Article  CAS  PubMed  Google Scholar 

  17. King RJ (1982) Pulmonary surfactant. J Appl Physiol 53:1–8

    Article  CAS  PubMed  Google Scholar 

  18. Krell WS, Staats BA, Hyatt RE (1986) Pulmonary function in relapsing polychondritis. Am Rev Respir Dis 133:1120–1123

    CAS  PubMed  Google Scholar 

  19. Matoba A, Plager S, Barber J, McCulley JP (1984) Keratitis in relapsing polychondritis. Ann Ophthalmol 16:367–370

    CAS  PubMed  Google Scholar 

  20. Mc Adam LP, O'Hanlan MA, Bluestone R, Pearson CM (1976) Relapsing polychondritis: Medicine 55:193–215

    CAS  Google Scholar 

  21. Pearson CM, Kline HM, Newcomer VD (1960) Relapsing polychondritis. N Engl J Med 263:51–58

    Article  CAS  PubMed  Google Scholar 

  22. Reynolds HY (1987) Bronchoalveolar lavage. Am Rev Respir Dis 135:250–263

    CAS  PubMed  Google Scholar 

  23. Whitsett JA, Ross G, Weaver T, Rice W, Dion C, Hull W (1985) Glycosylation and secretion of surfactant-associated glycoprotein A. J Biol Chem 260:15273–15279

    CAS  PubMed  Google Scholar 

  24. Williams MC, Hawgood S, Schenk DB, Lewicki J, Phelps MN, Benson B (1988) Monoclonal antibodies to surfactant proteins SP28-26 label canine type II and nonciliated bronchiolar cells by immunofluorescence. Am Rev Respir Dis 137:399–405

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medizinische Poliklinik der Universität München, Germany

    G. Rauh, H. Dörfler & N. Zöllner

  2. Anatomische Anstalt der Universität München, Lehrstuhl II, Germany

    R. Erlinger

  3. Augenklinik der Universität München, Germany

    K. G. Riedel

Authors
  1. G. Rauh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Dörfler
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Erlinger
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K. G. Riedel
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. N. Zöllner
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rauh, G., Dörfler, H., Erlinger, R. et al. Relapsing poly(peri)chondritis associated with fibrosing alveolar disease and antibodies to pneumocytes type II and clara cells. Klin Wochenschr 67, 784–789 (1989). https://doi.org/10.1007/BF01745351

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01745351

Key words

Search

Navigation