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Correlation of blood pressure in end-stage renal disease with platelet cytosolic free-calcium concentration

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Summary

The fluorescent probe Quin-2 showed the cytosolic free-calcium concentration in platelets to be elevated in 12 hypertensive hemodialysis patients, who were compared with 12 normotensive hemodialysis patients. There was a close correlation between the free-calcium level of platelets and mean arterial pressure (r=0.88). Short-term antihypertensive treatment resulted in a reduction of free-calcium concentration and a concomitant fall in blood pressure. These results suggest an integrative contributory role for calcium in the pathophysiology of hypertension accompanying endstage renal disease.

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  1. Medizinische Klinik Innenstadt der Universität München, Deutschland

    H. Schiffl

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Schiffl, H. Correlation of blood pressure in end-stage renal disease with platelet cytosolic free-calcium concentration. Klin Wochenschr 68, 718–722 (1990). https://doi.org/10.1007/BF01647579

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  • DOI: https://doi.org/10.1007/BF01647579

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