Abstract
Type A natriuretic peptide (CDD/ANP99-126) in its circulating form was analyzed with respect to the localization of its bronchodilating effects in asthmatic subjects in vivo. The intravenous infusion of 5.7, 11.4, and 17.1 pmol kg−1 min− CDD/ANP-99-126 caused a significant bronchodilation of both central and peripheral airways. While the localization of the bronchodilating effects was similar to β2-agonists, an improvement in lung function parameters comparable to these substances was not observed. But other members of the natriuretic peptide family may reveal a stronger bronchodilating potency.
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Abbreviations
- FEV:
-
forced expiratory volume in 1 s
- FVC:
-
forced vital capacity
- PEF:
-
peak expiratory flow
- MEF75, MEF50, MEF25 :
-
maximal expiratory flow at 75%, 50%, 25% of forced vital capacity
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Correspondence to: T. Edge
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Flüge, T., Fabel, H., Wagner, T.O.F. et al. Localization of the bronchodilator effect induced by type A natriuretic peptide in asthmatic subjects. Clin Investig 72, 772–774 (1994). https://doi.org/10.1007/BF00180545
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DOI: https://doi.org/10.1007/BF00180545