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Tetrapeptide acyl-hydrazide analogs of enkephalin

A new group of potent analgesics

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Abbreviations

EK:

enkephalin

Met(O):

methionine sulfoxide

Met(O)-ol:

methioninol sulfoxide

MePhe:

N-methyl-phenylalanine

Thz:

thiazolidine-4-carb-oxylic acid

Z:

benzyloxycarbonyl

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Author information

Authors and Affiliations

  1. Chemical Research Laboratories, Japan

    M. Fujino & S. Shinagawa

  2. Medicinal Research Laboratories, Central Research Division, Takeda Chemical Industries, Ltd., Juso-honmachi, Yodogawa-ku, 532, Osaka, Japan

    K. Kawai & H. Ishii

Authors
  1. M. Fujino
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  2. S. Shinagawa
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  3. K. Kawai
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  4. H. Ishii
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Additional information

The authors wish to express their gratitude to Drs. E. Ohmura, K. Morita, and M. Nishikawa for their encouragement throughout this work. We also thank Endo Laboratories, Garden City, New York, for the generous supply of naloxone.

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Fujino, M., Shinagawa, S., Kawai, K. et al. Tetrapeptide acyl-hydrazide analogs of enkephalin. Naturwissenschaften 66, 625–626 (1979). https://doi.org/10.1007/BF00405135

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  • DOI: https://doi.org/10.1007/BF00405135

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