Summary
Adult genetically obesefafa rats showed a high level of lipogenesis from glucose in liver but not in adipose tissue; pancreatic content and serum levels of insulin were elevated. Glucose uptake and insulin sensitivity were decreased in muscle,fafa rats and their lean littermates fed a high-fat diet showed increased fat deposits. Serum insulin levels were not significantly affected by diet in either group. The larger the fat cells were, the more actively they utilised glucose; insulin sensitivity was influenced both by diet and cell size. Control rats made obese by a high caloric diet did not show insulin resistance in muscle. — The data indicate that in adult obesity in these rats, even in the presence of marked hyperinsulinism, increased lipogenesis in adipose tissue is not a prerequisite. Rather, fat storage is a consequence of increased uptake of circulating triglycérides. On a diet rich in carbohydrate, adipose tissue fatty acids were mainly of hepatic origin; on a high-fat diet they were of dietary origin.
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Lemonnier, D., Aubert, R., Suquet, J.P. et al. Metabolism of genetically obese rats on normal or high-fat diet. Diabetologia 10 (Suppl 1), 697–701 (1974). https://doi.org/10.1007/BF01222007
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DOI: https://doi.org/10.1007/BF01222007