Summary
Streptozotocin diabetic rats have larger kidneys than non-diabetic rats. In the present study the rate of kidney growth during the first seven days of diabetes was correlated with the blood glucose concentration. Over a wide range of blood glucose concentrations (116–340 mg/100 ml) the kidney weight, protein content and protein/DNA ratio were closely correlated with the glucose values.
Article PDF
Similar content being viewed by others
References
Mogensen, C.E., Andersen, M.J.F.: Increased kidney size and glomerular filtration rate in untreated juvenile diabetes: normalization by insulin treatment. Diabetologia11, 221–224 (1975)
Seyer-Hansen, K.: Renal hypertrophy in streptozotocin diabetic rats. Clin. Sci. Mol. Med.51, 551–555 (1976)
Munro, H.N., Fleck, A.: The determination of nucleic acids. Methods Biochem. Anal.14, 113–176 (1966)
Burton, K.: A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem. J.62, 315–323 (1956)
Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randell, R.J.: Protein measurement with the Folin phenol reagent. J. Biol. Chem.193, 265–271 (1951)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Seyer-Hansen, K. Renal hypertrophy in experimental diabetes: Relation to severity of diabetes. Diabetologia 13, 141–143 (1977). https://doi.org/10.1007/BF00745142
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00745142