Summary
Injection of porcine growth hormone (200 μg) or saline 5 days a week for 16 to 20 weeks in streptozotocin-diabetic rats showed that compared to saline growth hormone produced a 2 1/2-fold larger increase in glomerular capillary basement membrane thickness (2p=0.027). The possible significance of this effect of an elevated level of growth hormone for diabetic microangiopathy is discussed.
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References
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Østerby, R., Seyer-Hansen, K., Gundersen, H.J.G. et al. Growth hormone enhances basement membrane thickening in experimental diabetes. Diabetologia 15, 487–489 (1978). https://doi.org/10.1007/BF02342875
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DOI: https://doi.org/10.1007/BF02342875