Summary
We have previously reported a slower rate of progression in the number of microaneurysms in insulin dependent diabetic patients treated by divided insulin injections when compared to patients receiving a single daily insulin injection [Diabetes 25, 463–469 (1976)]. This observation is strengthened by the present analysis which uses complementary data obtained after a further year follow up: the mean yearly increase in the number of microaneurysms was 9±1 in the single injection group and 3±1 in the multiple one (p < 0.001).
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Eschwege, E., Job, D., Guyot-Argenton, C. et al. Delayed progression of diabetic retinopathy by divided insulin administration: A further follow-up. Diabetologia 16, 13–15 (1979). https://doi.org/10.1007/BF00423144
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DOI: https://doi.org/10.1007/BF00423144