Summary
The absorption of subcutaneously injected insulin was examined by injecting semisynthetic [3H] insulin in anaesthetized pigs and subsequently analysing the tissue excised from the injection site. Contrary to previously accepted views, a significant proportion of insulin was degraded at the injection site. The disappearance of intact [3H] insulin from the injection site followed a monoexponential function with a half-time of 59 min.
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Berger, M., Halban, P.A., Girardier, L. et al. Absorption kinetics of subcutaneously injected insulin. Diabetologia 17, 97–99 (1979). https://doi.org/10.1007/BF01222209
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DOI: https://doi.org/10.1007/BF01222209