Summary
In normal fasting ducks, a somatostatin infusion (800 ng/kg/min for 30 min) elicited a prompt inhibition of insulin secretion, plasma levels falling from 140±20 to 20±6 pg Eq/ml as observed in mammals. — However plasma glucagon-like-immunoreactivity shown to be decreased in mammals by somatostatin was sharply increased from a mean basal level of 1.46±0.13 ng Eq/ml to 6.61±0.77 ng Eq/ml. This effect was not mediated via inhibition of growth hormone secretion since it was also observed in hypophysectomised ducks. Despite the fall in plasma insulin and rise in GLI observed with somatostatin infusion in intact birds, plasma glucose concentrations were lower than with control saline infusion.
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Benoit J (1937) Facteurs externes et internes de l'activité sexuelle. II. Etude du mécanisme de la stimulation par la lumière de l'activité testiculaire chez le canard domestique. Rôle de l'hypophyse. Bull Biol Fr Belge 121:394
Björkman O, Wahren J, Felig P (1978) Influence of somatostatin infusion on hepatic glucose metabolism in man (abstract). Diabetologia 15:220
Boden G, Sivitz MC, Owen EO, Essa-Koumar N, Landor JH (1975) Somatostatin suppresses secretin and pancreatic exocrine secretion. Science 190:163–165
Brazeau R, Vale W, Burgus R, Ling N, Butcher M, Rivier J, Guillemin R (1973) Hypothalamic polypeptide that inhibits the secretion of immunoreactive growth hormone. Science 179:77–79
Christensen SE, Hansen AP, Iversen J, Ørskov H, Seyer-Hansen K (1975) Somatostatin as a tool in studies of basal carbohydrate and lipid metabolism in man: modifications of glucagon and insulin release. Scand J Clin Lab Invest 34:321–325
Curry DL, Bennett LL, Li CH (1974) Direct inhibition of insulin secretion by synthetic somatostatin. Biochem Biophys Res Commun 58:885–889
Foltzer C, Leclercq-Meyer V, Mialhe P (1975) Pituitary and adrenal control of pancreatic endocrine function in the duck. I. Plasma glucose and pancreatic glucagon variations following hypophysectomy and replacement therapy by growth hormone and corticosterone. Diabète Métab 1:39–44
Foltzer C, Mialhe P (1976) Pituitary and adrenal control of pancreatic endocrine function in the duck. Diabète Métab 2:101–105
Gerich JE, Lorenzi M, Hane S, Gustafson G, Guillemin R, Forsham PH (1975) Evidence for a physiologic role of pancreatic glucagon in human glucose homeostasis: studies with somatostatin. Metabolism 24:175–182
Harvey S, Scanes CG (1977) Purification and radioimmunoassay of chicken growth hormone. J Endocrinol 73:321–329
Hoffman WS (1937) A rapid method for the determination of glucose in blood and urine. J Biol Chem 120:51–55
Ishida T (1977) Inhibitory effect of somatostatin on insulin and gastrin in dogs. Endocrinol Jpn 24:327–334
Johnson DG, Ensinck JW, Koerker D, Palmer J, Goodner CJ (1975) Inhibition of glucagon and insulin secretion by somatostatin in the rat pancreas perfused in situ. Endocrinology 96:370–374
Koerker DJ, Ruch W, Chideckel E, Palmer J, Goodner CJ, Ensinck J, Gale CC (1974) Somatostatin: hypothalamic inhibitor of the endocrine pancreas. Science 184:482–484
Laurent F, Mialhe P (1976) Insulin and the glucose-glucagon feedback mechanism in the duck. Diabetologia 12:23–33
Leclercq-Meyer V, Mialhe P, Malaisse WJ (1970) Une méthode de dosage radioimmunologique du glucagon comportant une séparation par le charbon-dextran. Diabetologia 6:121–129
Mialhe P (1958) Glucagon, insuline et régulation endocrine de la glycémie chez le canard. Acta Endocrinol [Suppl] (Kbh) 36:1–13
Mialhe P (1976) The role of glucagon in birds and mammals. In: Grillo TAI, Liebson L, Epple A (eds) The evolution of pancreatic islets. Pergamon Press, Oxford, p 291–300
Oliver JR, Wagle SR (1975) Studies on the inhibition of insulin release, glycogenolysis and glyconeogenesis by somatostatin in the rat islets of Langerhans and isolated hepatocytes. Biochem Biophys Res Commun 62:772–777
Orci L, Baetens D, Dubois MP, Rufener C (1975) Evidence for the D-cell of the pancreas secreting somatostatin. Horm Metab Res 7:400–402
Sacks H, Waligora K, Matthew J, Pimstone B (1977) Inhibition by somatostatin of glucagon induced glucose release from the isolated perfused rat liver. Endocrinology 101:1751–1759
Sakurai H, Dobbs R, Unger RH (1974) Somatostatin-induced changes in insulin and glucagon secretion in normal and diabetic dogs. J Clin Invest 54:1395–1402
Sitbon G, Mialhe P (1978) Pancreatic hormones and plasma glucose: regulation mechanisms in the goose under physiological conditions. III. Inhibitory effect of insulin on glucagon secretion. Horm Metab Res 10:473–477
Vale W, Rivier C, Brazeau P, Guillemin R (1974) Effects of somatostatin on the secretion of thyrotropin and prolactin. Endocrinology 95:968–977
Weir GC, Goltsos PC, Steinberg EP, Patel YC (1976) High concentrations of somatostatin immunoreactivity in chicken pancreas. Diabetologia 12:129–132
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Strosser, M.T., Cohen, L., Harvey, S. et al. Somatostatin stimulates glucagon secretion in ducks. Diabetologia 18, 319–322 (1980). https://doi.org/10.1007/BF00251013
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DOI: https://doi.org/10.1007/BF00251013