Summary
Cyclosporin A (50 mg/kg orally for 7 days) produced severe degranulation and hydropic degeneration of islet B cells in rats. These changes were accompanied by hyperglycaemia and hypoinsulinaemia, while the pancreatic insulin content decreased by 75%.
Article PDF
Similar content being viewed by others
References
Starzl TE (1983) Clinical aspects of cyclosporine therapy: a summation. Transplant Proc 15 (Suppl 1): 3103–3107
Ota B, Bradley M (1983) Side effects of cyclosporine in 100 renal allograft recipients. Transplant Proc 15 (Suppl 1): 3150–3156
Ryffel B, Donatsch P, Madörin M, Matter BE, Rüttimann G, Schön H, Stoll R, Wilson J (1983) Toxicological evaluation of cyclosporin A. Arch Toxicol 53: 107–141
Homan WP, Fabre JW, Williams KA, Millard PR, Morris PJ (1980) Studies of the immunosuppressive properties of cyclosporin A in rats receiving renal allografts. Transplantation 29: 361–366
Creutzfeldt W (1957) Alpha cell cytotoxins. Diabetes 6: 135–145
Kahan BD, Ried M, Newburger J (1983) Pharmacokinetics of cyclosporine in human renal transplantation. Transplant Proc 15: 446–453
Hahn HJ, Laube F, Klöting I, Kauert C, Lucke S, Besch W (1984) Effect of cyclosporin A on rat pancreatic β-cells in vivo and in vitro. Europ J Clin Invest 14 (2): 132 A
Gunnarsson R, Klintmalm G, Lundgren G, Wilczek H, Östman J, Groth CG (1983) Deterioration in glucose metabolism in pancreatic transplant recipients given cyclosporin. Lancet 2: 571–572
Stiller CR, Dupré J, Gent M, Jenner MR, Keown PA, Laupacis A, Martell R, Rodger NW, Graffenried BV, Wolfe BMJ (1984) Effect of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset. Science 223: 1362–1367
Rebuck AS, Stiller CR, Braude AC, Laupacis A, Cohen RD, Chapman KR (1984) Cyclosporin for pulmonary sarcoidosis. Lancet 1: 1174
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Helmchen, U., Schmidt, W.E., Siegel, E.G. et al. Morphological and functional changes of pancreatic B cells in cyclosporin A-treated rats. Diabetologia 27, 416–418 (1984). https://doi.org/10.1007/BF00304861
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00304861