Summary
Postprandial plasma glucose, insulin and C-peptide profiles were studied in eight normal subjects, in the afternoon or in the evening. Two to five synchronous oscillations, with a mean period of 51 to 112 min were detected. The oscillations were highest after meals and were then damped, reverting to fasting levels after up to 340 min. Additional short-term oscillations, with periods of 20–30 min and 9–14 min, were observed. Cross-correlation studies of glucose and insulin and of insulin and C-peptide revealed a high correlation in the frequency bands considered. The synchronous oscillations of insulin and C-peptide suggest cyclic variations in pancreatic secretion rather than cyclic changes in insulin degradation.
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Simon, C., Follenius, M. & Brandenberger, G. Postprandial oscillations of plasma glucose, insulin and C-peptide in man. Diabetologia 30, 769–773 (1987). https://doi.org/10.1007/BF00275742
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DOI: https://doi.org/10.1007/BF00275742