Conclusions
Considerations of the structure of a candidate initiating antigen have led us to propose a new model for the susceptibility to Type 1 diabetes. It is quite likely there are other antigens of similar structure of viral or bacterial origin that will provoke a similar response directed against islet beta cells. However, we believe that this hypothesis will provide a framework for the further investigation and research into the mechanism of development of Type 1 diabetes and for the design of therapeutic manoeuvres for its prevention.
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Robinson, B.H., Dosch, H.M., Martin, J.M. et al. A model for the involvement of MHC class II proteins in the development of Type 1 (insulin-dependent) diabetes mellitus in response to bovine serum albumin peptides. Diabetologia 36, 364–368 (1993). https://doi.org/10.1007/BF00400243
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DOI: https://doi.org/10.1007/BF00400243