Summary
The primary goal of the present study was to examine the effects of improved glycaemic control associated with glipizide treatment on postprandial lipaemia in non-insulin-dependent diabetic patients. The metabolism of triglyceride-rich lipoproteins of intestinal origin was assessed by measuring the retinyl palmitate content in plasma and the Svedberg flotation index (Sf)>400 and Sf 20–400 lipoprotein fractions. Fasting plasma glucose concentrations (14.5±0.5 vs 9.0±0.5 mmol/l), glycated haemoglobin levels (13.1±0.6 vs 9.7±0.6%), and daylong plasma glucose concentrations were all significantly lower after glipizide treatment (p<0.001). The improvement in glycaemic control was associated with increases in insulin-mediated glucose uptake (p<0.001) and plasma post-heparin lipoprotein and hepatic lipolytic activities (p<0.02). Both fasting plasma triglyceride (3.09±0.51 vs 2.37±0.34 mmol/l), and postprandial triglyceride concentrations (p<0.05–0.001) were lower following glipizide treatment, associated with a significant fall in retinyl palmitate content in all three lipoprotein fractions (p<0.02–0.001), with the most substantial decrease seen in the Sf 20–400 fraction. These data indicate that glipizide-induced improvement in glycaemic control was associated with changes in the metabolism of triglyceride-rich lipoproteins of intestinal origin that would be anticipated to reduce risk of coronary heart disease in non-insulin-dependent diabetic patients.
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Abbreviations
- RP:
-
Retinyl palmitate
- Sf:
-
Sverdberg flotation index
- CHD:
-
coronary heart disease
- SSPI:
-
steady-state plasma insulin concentration
- SSPG:
-
steady-state plasma glucose concentration
- IDL:
-
intermediate density lipoprotein
- NEFA:
-
non-esterified fatty acid; non-insulin-dependent diabetes mellitus
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Jeppesen, J., Zhou, M.Y., Chen, Y.D.I. et al. Effect of glipizide treatment on postprandial lipaemia in patients with NIDDM. Diabetologia 37, 781–787 (1994). https://doi.org/10.1007/BF00404335
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DOI: https://doi.org/10.1007/BF00404335