Article PDF
References
Ikegami H, Kawaguchi Y, Yamato E et al. (1992) Analysis by the polymerase chain reaction of histocompatibility leucocyte antigen-DR9-linked susceptibility to insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 75: 1381–1385
Kirk RL, Serjeantson SW, Theophilus J, Zimmet P, Whitehouse S, Court JM (1979) Age relationship between insulin-dependent diabetes and rare alleles of properdin factor B. Lancet II: 537
Bertrams J, Baur MP, Grüneklee D, Gries FA (1981) Agerelated association of insulin-dependent diabetes mellitus with BfF1 and the HLA-B18, BfF1 haplotype. Diabetologia 21: 47–49
Caillat-Zucman S, Garchon H-J, Timsit J et al. (1992) Age-dependent HLA genetic heterogeneity of type 1 insulin-dependent diabetes mellitus. J Clin Invest 90: 2242–2250
Tuomilehto-Wolf E, Tuomilehto J (1993) Is the high incidence of diabetes in young children diagnosed under the age of 4 years determined by genetic factors in Finland? The DIME Study. Diabete Metab 19: 167–172
Kawaguchi Y, Ikegami H, Fukuda M et al. (1994) Absence of association of TAP and LMP genes with type I (insulin-dependent) diabetes mellitus. Life Sciences 54: 2049–2053
Trucco G, Fritsch R, Giorda R, Trucco M (1989) Rapid detection of IDDM susceptibility with HLA-DQ Β-alleles as markers. Diabetes 38: 1617–1622
Kawaguchi Y, Ikegami H, Fukuda M, Fujioka Y, Shima K, Ogihara T (1993) Polymorphism of HSP70 gene is not associated with type 1 (insulin-dependent) diabetes mellitus in Japanese. Diabetes Res Clin Pract 21: 103–107
Demaine AG, Hibbered ML, Mangles D, Millward BA (1995) A new marker in the HLA class I region is associated with the age at onset of IDDM. Diabetologia 38: 623–628
Faustman D, Li X, Lin HY et al. (1991) Linkage of faulty major histocompatibility complex class I to autoimmune diabetes. Science 254: 1756–1761
Ikegami H, Kawaguchi Y, Ueda H et al. (1993) MHC-linked diabetogenic gene of the NOD mouse: molecular mapping of the 3′ boundary of the diabetogenic region. Biochem Biophys Res Commun 192: 677–682
Miyazaki T, Matsuda Y, Toyonaga T, Miyazaki J-I, Yazaki Y, Yamamura K-I (1992) Prevention of autoimmune insulitis in nonobese diabetic mice by expression of major histocompatibility complex class I Ld molecules. Proc Natl Acad Sci USA 89: 9519–9523
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ikegami, H. Class I HLA is associated with age-at-onset of IDDM, while class II HLA confers susceptibility to IDDM. Diabetologia 38, 1493–1495 (1995). https://doi.org/10.1007/BF00400620
Issue Date:
DOI: https://doi.org/10.1007/BF00400620