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Are insulin resistance and atherosclerosis the consequences of oxidative stress?

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References

  1. Ceriello A, Pirisi M (1995) Is oxidative stress the missing link between insulin resistance and atherosclerosis? Diabetologia 38: 1484–1485 (Letter)

    Article  PubMed  CAS  Google Scholar 

  2. Fujiwara Y, Kondo T, Murakami K, Kawakami Y (1989) Decrease of the inhibition of lipid peroxidation by glutathione-dependent system in erythrocytes of non-insulin dependent diabetics. Klin Wochenschr 67: 336–341

    Article  PubMed  CAS  Google Scholar 

  3. Trovati M, Massucco P, Mattiello L, et al. (1995) Insulin increases cyclic mucleotide content in human vascular smooth muscle cells: a mechanism potentially involved in insulin induced modulation of vascular tone. Diabetologia 38: 936–941

    Article  PubMed  CAS  Google Scholar 

  4. Marczin N, Ryan US, Catravas JD (1992) Methylene blue inhibits nitrovasodilator- and EDRF-induced cGMP accumulation in cultured pulmonary arterial smooth muscle cells via generation of superoxide anion. J Pharmacol Exp Ther 263: 170–179

    PubMed  CAS  Google Scholar 

  5. Oemar BS, Yang Z, Lüscher T (1995) Molecular and cellular mechanism of atherosclerosis. Curr Opin Nephrol Hypertens 4: 82–91

    Article  PubMed  CAS  Google Scholar 

  6. Murer EH, Gyda MA, Martinez NJ (1994) Insulin increases the aggregation response of human platelets to ADP. Thrombos Res 73: 69–74

    Article  CAS  Google Scholar 

  7. Charo IF, Feinman RD, Detweiler TC (1977) Interrelation of platelet aggregation and secretion. J Clin Invest 60: 866–873

    Article  PubMed  CAS  Google Scholar 

  8. Moncada S, Palmer RMJ, Higgs EA (1991) Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 43: 109–142

    PubMed  CAS  Google Scholar 

  9. Reaven GM (1995) The fourth Musketeer — from Alexandre Dumas to Claude Bernard. Diabetologia 38: 3–13

    Article  PubMed  CAS  Google Scholar 

References

  1. Ross R (1986) The pathogenesis of atherosclerosis; an update. N Engl J Med 314: 488–500

    PubMed  CAS  Google Scholar 

  2. Cureio F, Pegoraro I, Dello Russo P, Falleti E, Perrella G, Ceriello A (1995) SOD and GSH inhibit the high glucose-induced oxidative damage and the PDGF increased secretion in cultured human endothelial cells. Thromb Haemostas 74: 969–973

    Google Scholar 

  3. Sundaresan M, Yu ZX, Ferrans VJ, Irani K, Finkel T (1995) Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 270: 296–299

    Article  PubMed  CAS  Google Scholar 

  4. Muchmore DB, Little SA, de Haen C (1982) Counterregulatory control of intracellular hydrogen peroxide production by insulin and lypolitic hormones in isolated rat epididymal fat cells: a role for free fatty acids. Biochemistry 21: 3886–3892

    Article  PubMed  CAS  Google Scholar 

  5. Raines EW, Dower SK, Ross R (1989) Interleukin-I mitogenic activity for fibroblasts and smooth muscle cells is due to PDGF-AA. Science 247: 393–396

    Article  Google Scholar 

  6. Stout RW, Bierman EL, Ross R (1975) Effects of insulin on the proliferation of cultured primate arterial smooth muscle cells. Circ Res 36: 319–327

    PubMed  CAS  Google Scholar 

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Wittmann, I., Ceriello, A. Are insulin resistance and atherosclerosis the consequences of oxidative stress?. Diabetologia 39, 1002–1003 (1996). https://doi.org/10.1007/BF00403924

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