Abstract
Paraoxon exerts its antilipolytic effect on the lipolytic system of fat cells by a direct interaction with the triglyceride lipase. It does not affect other components of the lipolytic system such as adenyl cyclase, phosphodiesterase, ATP-levels or binding of cyclic 3′,5′-AMP-dependent protein kinase. Phosphorylation of protein mediated by cyclic 3′,5′-AMP-dependent protein kinase is not impaired by paraoxon.
Zusammenfassung
Paraoxon übt seine antilipolytische Wirkung auf das lipolytische System der Fettzelle durch einen direkten Einfluß auf die Triglyceridlipase aus. Es beeinflußt nicht andere Komponenten dieses Systems wie die Adenylcyclase, die Phosphodiesterase, den ATP-Gehalt der Zellen und die Bindungskapazität der cyclisch 3′,5′-AMP abhängigen Proteinkinase. Die durch diese Proteinkinase bewirkte Phosphorylierung von Protein wird ebenfalls nicht durch Paraoxon gehemmt. Somit erscheint die Fettzelle als geeignet, direkte Beeinflussung der esterasehemmenden Wirkung von Alkylphosphaten durch Antidote in einer lebenden Zelle zu erfassen.
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Dinnendahl, V., Peters, H.D., Helm, U.K. et al. Studies on the mechanism of the antilipolytic effect of paraoxon. Arch Toxicol 30, 175–182 (1973). https://doi.org/10.1007/BF02425934
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DOI: https://doi.org/10.1007/BF02425934