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Interaction between glucose diet and ethanol on rat liver microsomal induction and liver plasma membrane damage in chronic hexachlorobenzene intoxication

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  • Mechanisms of Cellular Toxicity
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Abstract

Male Wistar rats fed for 60 days a glucose diet containing 17.5 mmol hexachlorobenzene/kg show a less pronounced increase in serum parameters and microsomal cytochrome P-450 concentration and a lower decrease in liver plasma membrane 5′-nucleotidase, K+, Na+- and Mg++-adenosine triphosphatase activities than the controls fed standard diet + hexachlorobenzene. Addition of 10% ethanol to the drinking water eliminates the “glucose effect”. The glucose diet and ethanol exert contrasting effects on microsomal enzyme induction and liver plasma membrane damage in hexachlorobenzene intoxication.

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Dedicated to Professor Dr. med. Herbert Remmer on the occasion of his 65th birthday

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Nikolaev, V., Naydenova, E., Kerimova, M. et al. Interaction between glucose diet and ethanol on rat liver microsomal induction and liver plasma membrane damage in chronic hexachlorobenzene intoxication. Arch Toxicol 60, 112–114 (1987). https://doi.org/10.1007/BF00296961

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  • DOI: https://doi.org/10.1007/BF00296961

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