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Renal handling of cadmium and cadmium-metallothionein: studies on the isolated perfused rat kidney

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Abstract

The isolated kidney perfusion model was used to study the uptake of Cd and metallothionein (MT)-complexed Cd. Cd2+ at concentrations above 40 nM strongly depressed the glomerular filtration rate (GFR), whereas MT-complexed Cd (Cd-MT) at concentrations of 0.8–920 nM had no effect on the GFR. In contrast to Cd2+, Cd-MT was readily reabsorbed by the kidney and uptake saturation for Cd-MT occured at 240 nM. The maximal transport rate for Cd-MT calculated in this study was 18 pmoles Cd-MT· g−1·min−1. The accumulation of Cd in the kidney was more efficient in the experiment using Cd-MT, in which case the Cd kidney contents were about 2–4 times higher than compared to CdCl2.

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Authors and Affiliations

  1. Department of Toxicology, Düsseldorf, Medical Institut of Environmental Hygiene, D-4000, Düsseldorf, Germany

    J. Abel & D. Höhr

  2. Center of Internal Medicine, Department of Nephrology, Hannover Medical School, D-3000, Hannover, Germany

    H. -J. Schurek

Authors
  1. J. Abel
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  2. D. Höhr
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  3. H. -J. Schurek
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Abel, J., Höhr, D. & Schurek, H.J. Renal handling of cadmium and cadmium-metallothionein: studies on the isolated perfused rat kidney. Arch Toxicol 60, 370–375 (1987). https://doi.org/10.1007/BF00295757

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  • DOI: https://doi.org/10.1007/BF00295757

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