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The metabolic origin of the sulfur atom in the sulfhydryl group of 2-thiobenzothiazole metabolites derived from benzothiazyl sulfenamide in the rat

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Abstract

After administration of benzothiazyl sulfenamide to rats, over 90% of the S atom in the sulfhydryl group was retained in 2-thiobenzothiazole metabolites. The S atom in 2-benzothiazyl mercapturic acid, a major metabolite, was mostly replaced by the endogenous S from thel-cysteine pool.

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Abbreviations

TBT:

2-thiobenzothiazole

BTMA:

2-benzothiazyl mercapturic acid

ODEBT:

N-oxydiethylene-2-benzothiazole

MBT:

2-mercaptobenzothiazole

BTDS:

2,2′-dibenzothiazyl disulfide

GSH:

glutathione

MSO:

l-methionine-SR-sulfoximine

References

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Authors and Affiliations

  1. Division of Biological Chemistry, National Institute of Hygienic Sciences, Kamiyoga-1-chome, Setagaya-ku, 158, Tokyo, Japan

    M. Fukuoka & A. Tanaka

Authors
  1. M. Fukuoka
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  2. A. Tanaka
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Fukuoka, M., Tanaka, A. The metabolic origin of the sulfur atom in the sulfhydryl group of 2-thiobenzothiazole metabolites derived from benzothiazyl sulfenamide in the rat. Arch Toxicol 61, 158–160 (1987). https://doi.org/10.1007/BF00661376

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  • DOI: https://doi.org/10.1007/BF00661376

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