Skip to main content

Advertisement

SpringerLink
Log in

The carcinogenicity of diethylstilbestrol: structural evidence for a non-genotoxic mechanism

  • ORIGINAL INVESTIGATION
  • Published:
Archives of Toxicology Aims and scope Submit manuscript

Abstract

 An analysis of the structure of diethylstilbestrol (DES) indicates that neither DES nor any of its metabolites are potential mutagens. Moreover, the present analyses suggest (a) that the observed carcinogenic spectrum of DES reflects the activity of metabolic intermediates and (b) that the carcinogenicity of DES in mice is due to the presence of a 6 Å geometric descriptor that appears to be related to an estrogen receptor.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15238, USA, , , , , , US

    A. Cunningham & H. S. Rosenkranz

  2. Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA, , , , , , US

    G. Klopman

Authors
  1. A. Cunningham
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Klopman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. S. Rosenkranz
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Received: 20 June 1995/Accepted: 21 August 1995

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cunningham, A., Klopman, G. & Rosenkranz, H. The carcinogenicity of diethylstilbestrol: structural evidence for a non-genotoxic mechanism. Arch Toxicol 70, 356–361 (1996). https://doi.org/10.1007/s002040050285

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s002040050285

Search

Navigation