Summary
Ethanol 2 g kg−1 i.p. to rat increased the concentrations in the brain of administered large neutral amino acids (tyrosine, tryptophan, 5-hydroxytryptophan and α-methyldopa). We have previously found a similar effect of ethanol on administered l-Dopa, resulting in increased brain/plasma ratios of dopa. Since large neutral amino acids are known to compete with each other for the carrier-mediated transport into the brain we suggest that the increased concentrations of the administered amino acids in the brain are at least partly the consequence of the ethanol-induced decrease in plasma amino acids observed previously.
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Eriksson, T., Carlsson, A. Ethanol-induced increase in brain concentrations of administered neutral amino acids. Naunyn-Schmiedeberg's Arch. Pharmacol. 314, 47–50 (1980). https://doi.org/10.1007/BF00498430
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DOI: https://doi.org/10.1007/BF00498430