Summary
The purpose of the present study was to further characterize the α-adrenoceptors located on parasympathetic fibres. Segments of guinea-pig ileum were stimulated by transmural electrical pulses, and the ensuing contractions, which are due to the release of acetylcholine from postganglionic parasympathetic fibres, were monitored. Clonidine and tramazoline, which are thought to act preferentially on presynaptic α-adrenoceptors, reduced the contractions, whereas phenylephrine and methoxamine, postsynaptic α-adrenoceptor agonists, were ineffective. Contractions induced by acetylcholine were not changed by clonidine but were abolished by atropine. Yohimbine, piperoxan, phentolamine and thymoxamine reversed or prevented the inhibitory effect of clonidine. Prazosin and AR-C239 did not antagonize this effect. The inhibitory effect of tramazoline was antagonized by piperoxan but not by AR-C239 or by prazosin. Naloxone did not alter the action of clonidine, and piperoxan did not change the inhibitory effect of morphine.
In conclusion, these experiments suggest the presence on cholinergic postganglionic fibres of both opiate receptors and α-adrenoceptors. The latter appear to resemble more closely α1-adrenoceptors than α1-adrenoceptors.
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Andréjak, M., Pommier, Y., Mouillé, P. et al. Effects of some α-adrenoceptor agonists and antagonists on the guinea-pig ileum. Naunyn-Schmiedeberg's Arch. Pharmacol. 314, 83–87 (1980). https://doi.org/10.1007/BF00498434
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DOI: https://doi.org/10.1007/BF00498434