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The role of histamine and catecholamines in anaphylatoxin shock as compared to the anaphylactic shock

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Summary

  1. 1.

    In the heart lung preparation (HLP) of the guinea pig 2.5 ml rat serum anaphylatoxin (AT) released approximately ten times less histamine than was released by 5 mg ovalbumin in the sensitized HLP. In intact animals the plasma histamine increase caused by 5 ml/kg AT was not significantly different from that caused by 10 mg/kg ovalbumin. It is supposed that in AT shock extrapulmonary sources contribute to plasma histamine more than in anaphylactic shock.

  2. 2.

    Mepyramine maleate (40 μg/ml blood) did not significantly reduce the bronchospasm caused by AT in HLP except when a very high AT dose (0.3 ml/ml) was given. In the intact animal, mepyramine lowered the AT-induced bronchospasm by 50–65%. This effect of mepyramine is completely abolished byβ-adrenoceptive receptor blockade.

  3. 3.

    It is concluded that the prevalence of histamine effects in AT shock in vivo, as documented by the life saving effect of antihistamines, is due to 2 facts: influx of histamine from the organs other than the lung, and preferential antagonism by catecholamines of such shock mechanisms which are not based on histamine release.

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  1. Institute of Pharmacology of the University of Freiburg i. Br., Germany

    W. Bernauer, F. Hahn, E. Beck & H. Kury

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  1. W. Bernauer
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  2. F. Hahn
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  3. E. Beck
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  4. H. Kury
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Bernauer, W., Hahn, F., Beck, E. et al. The role of histamine and catecholamines in anaphylatoxin shock as compared to the anaphylactic shock. Naunyn-Schmiedebergs Arch. Pharmak. 266, 208–222 (1970). https://doi.org/10.1007/BF00997283

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