Summary
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1.
Injections of cobaltous chloride (5 mg/rat) on ten consecutive days, producing heart insufficiency, increase the specific activity of the sodium-potassiumactivated ATPase of the vesicle-fraction by about 100%.
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2.
After only one injection of 5 or 7.5 mg cobaltous chloride the activity of the Na+ + K+-ATPase is not increased. The activity of the enzyme from kidneys is not increased before the fourth injection, whereas in the heart an increase is found after the second injection. Even after ten injections the increase of activity of the enzyme from heart muscle is more than that of the enzyme from kidneys.
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3.
In adrenalectomized as well as in metyrapone-pretreated rats cobaltous chloride increases the enzyme activity. Therefore this increase cannot be caused by a stimulation of the adrenal cortex. We propose that repeated administrations of cobaltous chloride cause a cardiac insufficiency combined with structural alterations of the membranes of the sarcoplasmatic reticulum which change the activity of membrane-bound enzymes.
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Die Ergebnisse wurden auf der 11. Frühjahrstagung der Deutschen Pharmakologischen Gesellschaft am 18. MÄrz 1970 in Mainz vorgetragen.
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Dransfeld, H., Lipinski, J. & Borsch-Galetke, E. Die Na+ + K+- aktivierte Transport-ATPase bei experimenteller Herzinsuffizienz durch Kobaltchlorid. Naunyn-Schmiedebergs Arch. Pharmak. 270, 335–342 (1971). https://doi.org/10.1007/BF01002345
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DOI: https://doi.org/10.1007/BF01002345