Summary
After a single i.v. administration of 50 mg/kg of Trimethoprim (TM) to rats in late pregnancy, a diffusion equilibrium of the folic acid inhibitor in the foetal organs is reached after 30–60 min. The TM levels in maternal as well as in foetal organs can have an inhibitory effect on folic acid reductase activity.
The elimination of TM is lower in pregnant than in non-pregnant animals. The TM elimination of the foeti is dependent on the elimination capacity of the mother.
Three-days-old rats eliminate TM some four times slower than mature animals owing to their reduced kidney development.
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Schulz, R. Distribution and elimination of trimethoprim in pregnant and newborn rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 272, 369–377 (1972). https://doi.org/10.1007/BF00501243
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DOI: https://doi.org/10.1007/BF00501243