Summary
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1.
In male rats DAO was found to be absent in plasma and liver, very low in gastric and high in the upper small intestinal mucosa.
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2.
Gastric mucosal DAO was completely abolished by 10−8 M Brocresine. In the small intestine inhibition of DAO by Brocresine was dose-dependent, with a concentration of 6.2×10−6 M producing a 50% inhibition of the enzyme.
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3.
Pretreatment of rats with 100 mg/kg Brocresine i.p. produced a 43% inhibition of DAO after 1 h and an insignificant inhibition by 20% after 4 h.
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4.
The results suggest that the histidine decarboxylase inhibitor Brocresine is not a very suitable tool for studying the physiological role of histamine by inhibiting its biosynthesis since it also interferes with the histamine catabolism.
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Binder, B., Sewing, K.F. The effect of brocresine (NSD-1055) on diamine oxidase activity in plasma, liver, stomach and upper small intestine of rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 278, 425–430 (1973). https://doi.org/10.1007/BF00501484
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DOI: https://doi.org/10.1007/BF00501484