Summary
The application of disodium dichloromethylene diphosphonate (Cl2MDP), a diphosphonate which is known to inhibit bone formation and bone destruction leads to changes in the metabolism of 25-Hydroxycholecalciferol. The concentration of the tissue active form of vitamin D, i.e. 1,25-Dihydroxycholecalciferol, was found to be markedly diminished in blood serum, kidney and intestine. It is discussed whether this finding is due to a direct effect of Cl2MDP on 25-Hydroxycholecalciferol-1-hydroxylase in the kidney or indirectly caused by a disturbance of the regulation of 1,25-Dihydroxycholecalciferol production.
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von Herrath, D., Kraft, D. & Schaefer, K. Influence of disodium dichloromethylene diphosphonate on 25-hydroxycholecalciferol metabolism in rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 278, 435–440 (1973). https://doi.org/10.1007/BF00501486
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DOI: https://doi.org/10.1007/BF00501486