Summary
A male human subject administered single, oral doses of ethanol was examined repeatedly for venous ethanol levels. Four separate trials, begun at 03.00, 09.00, 15.00, and 21.00 h, on different days yielded four different estimates of the slope of the apparently linear ethanol disappearance curve. The slopes appeared to exhibit circadian rhythmicity. In a second study of the same subject, the slope was estimated 7 times over a period of 26 h following repeated oral doses. These slopes also appeared to vary in a daily fashion. These preliminary results suggest that pharmacokinetic parameters may not be invariable with time of day.
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Abele, G.: Die Abhängigkeit des Faktors β von der Konzentrationshöhe. Dtsch. Z. gericht. Med. 44, 374–382 (1955)
Carter, D. E., Bressler, R., Hughes, M. R., Haussler, M. R., Christian, C. D., Heine, M. W.: Effect of oral contraceptives on plasma clearance. Clin. Pharmacol. Ther. 18, 700–707 (1975)
Dost, F. H.: Grundlagen der Pharmakokinetik, 2nd ed. Stuttgart: Thieme 1968
Elbel, H., Schleyer, F.: Blutalkohol. Die wissenschaftlichen Grundlagen der Beurteilung von Blutalkoholbefunden bei Straßenverkehrsdelikten, 2nd ed. Stuttgart, Thieme 1956
Grüner, O., Sattler, H.: Untersuchungen über den Einfluß orthostatisch bedingter Blut- und Wasserverschiebungen auf den Verlauf der Blutalkoholkurve. Dtsch. Z. gericht. Med. 47, 276–281 (1958)
Halberg, F.: From aniatrotoxicosis and aniatrosepsis toward chemotherapy. In: Chronobiological aspects of endocrinology (J. Aschoff, F. Ceresa, and F. Halberg, eds.), pp. 1–33. Stuttgart: Schattauer 1974
Halberg, F., Tong, Y. L., Johnson, E. A.: Circadian system phase.—An aspect of temporal morphology; procedures and illustrative examples. In: The cellular aspects of biorhythms (H. von Mayersbach, ed.), pp. 20–48. Berlin-Heidelberg-New York: Springer 1967
Haus, E.: Periodicity in response and susceptibility to environmental stimuli. Ann. N. Y. Acad. Sci. 117, 292–319 (1964)
Hawkins, R. D., Kalant, H.: The metabolism of ethanol and its metabolic effects. Pharmacol. Rev. 24, 67–157 (1972)
Jones, B. M.: Circadian variation in the effects of alcohol on cognitive performance. Quart. J. Stud. Alcohol 35, 1212–1219 (1974)
Jones, B. M., Jones, M. K.: Effects of a moderate dose of alcohol on female social drinkers at different times in the menstrual cycle. Chronobiologia, Suppl. 1, 34 (1975)
Krieger, D. T.: Factors influencing the circadian periodicity of plasma corticosteroid levels. Chronobiologia 1, 195–216 (1974)
Krieger, D. T.: Rhythms of ACTH and corticosteroid secretion in health and disease, and their experimental modification. J. Ster. Biochem. 6, 785–791 (1975)
Levy, G.: Effect of bed rest on distribution and elimination of drugs. J. pharmaceut. Sci. 56, 928–929 (1967)
Lucis, O. J., Lucis, R.: Oral contraceptives and endocrine changes. Bull. Wld Hlth Org. 46, 443–450 (1972)
Lundquist, F., Wolthers, H.: The kinetics of alcohol elimination in man. Acta pharmacol. (Kbh.) 14, 265–289 (1958)
Moore Ede, M. C.: Circadian rhythms of drug effectiveness and toxicity. Clin. Pharmacol. Ther. 14, 925–935 (1973)
Nelson, W., Halberg, F.: An evaluation of time-dependent changes in susceptibility of mice to pentobarbital injection. Neuropharmacology 12, 509–524 (1973)
Newman, H. H.: Acute alcoholic intoxication. A critical review. Stanford Univ. Press 1941
Pauly, J. E., Scheving, L. E., Sturtevant, F. M., Sturtevant, R. P.: Evidence for circadian variation in the metabolism of ethanol in man. Proc. X. Int. Cong. Anat., Tokyo, p. 522 (1975)
Procacci, P., Della Corte, M., Zoppi, M., Maresca, M.: Rhythmic changes of the cutaneous pain threshold in man. A general review. Chronobiologia 1, 77–96 (1974)
Reinberg, A., Halberg, F.: Circadian chronopharmacology. Ann. Rev. Pharmacol. 11, 455–492 (1971)
Reinberg, A., Clench, J., Aymard, N., Galliot, M., Bourdon, R., Gervais, P., Abulker, C., Dupont, J.: Rhythmes circadiens des paramètres de l'éthanolémie provoquée chez six hommes adultes, jeunes et sains. C. R. Acad. Sci. (Paris) 278, 1503–1505 (1974)
Rutenfranz, J., Singer, R.: Untersuchungen zur Frage einer Abhängigkeit der Alkoholwirkung von der Tageszeit. Int. Z. angew. Physiol. 24, 1–17 (1967)
Scheving, L. E., von Mayersbach, H., Pauly, J. E.: An overview of chronopharmacology. J. Europ. Toxicol. 7, 203–227 (1974)
Schønheyder, F., Petersen, O. S., Terkildsen, K., Petersen, V. P.: On the variation of the alcoholemic curve. Acta med. scand. 109, 460–470 (1942)
Stupfel, M.: Biorhythms in toxicology and pharmacology. I. Generalities, ultradian and circadian biorhythms. Biomedicine 22, 18–24 (1975)
Sturtevant, F. M.: Chronopharmacokinetics of ethanol. I. Review of the literature and theoretical considerations. Chronobiologia (in press, 1976)
Sturtevant, F. M., Sturtevant, R. P., Scheving, L. E., Pauly, J. E.: Chronopharmacokinetics of ethanol in man. Chronobiologia, Suppl. 1, 69 (1975a)
Sturtevant, F. M., Sturtevant, R. P., Scheving, L. E., Pauly, J. E.: Chronopharmacokinetics of ethanol in man. Pharmacologist 17, 194 (1975b)
Swoyer, J., Lakatua, D. J., Haus, E., Warner, T., Sackett, L.: Circadian rhythm in ethanol disappearance rate from human plasma. Chronobiologia, Suppl. 1, 72 (1975)
Van Cauter, E., Golstein, J., Vanhaelst, L., Leclerq, R.: Effects of oral contraceptive therapy on the circadian patterns of cortisol and thyrotropin (TSH). Europ. J. clin. Invest. 5, 115–121 (1975)
Vekemans, M., Robyn, C.: The influence of exogenous estrogen on the circadian periodicity of circulating prolactin in women. J. clin. Endocr. 40, 886–889 (1975)
Wagner, J. G., Patel, J. A.: Variations in absorption and elimination rates of ethyl alcohol in a single subject. Res. Commun. chem. Path. Pharmacol. 4, 61–76 (1972)
Wallgren, H.: Absorption, diffusion, distribution and elimination of ethanol. Effect on biological membranes. In: Alcohols and derivatives, Vol. I, International Encyclopedia of Pharmacology and Therapeutics, pp. 161–188. London: Pergamon 1970
Widmark, E. M. P.: Les lois cardinales de la distribution et du métabolisme de l'alcool éthylique dans l'organisme humain. Kungl. fysiograf. Sällskapets Hanlingar. N.F. 41, 1–58 (1930)
Wilson, R. H. L., Newman, E. J., Newman, H. W.: Diurnal variation in rate of alcohol metabolism. J. appl. Physiol. 8, 556–558 (1956)
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Preliminary accounts were presented in part before the International Society for Chronobiology, Bethesda, Maryland, August 13, 1975; The American Society for Pharmacology and Experimental Therapeutics, Davis, California, August 19, 1975; and the X. International Congress of Anatomists, Tokyo, Japan, August 27, 1975 (Sturtevant et al., 1975a, b; Pauly et al., 1975).
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Sturtevant, F.M., Sturtevant, R.P., Scheving, L.E. et al. Chronopharmacokinetics of ethanol. Naunyn-Schmiedeberg's Arch. Pharmacol. 293, 203–208 (1976). https://doi.org/10.1007/BF00507342
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DOI: https://doi.org/10.1007/BF00507342