Summary
5,7-Dihydroxytryptamine lesions of the nucleus accumbens septi, or substantia nigra, resulted in a twofold increase in spontaneous locomotor activity. Striatal 5HT depletion also raised basal activity levels, as well as increasing rearing behaviour in an open field. The stereotyped responses to all doses of amphetamine tested (2.5–10 mg/kg, i.p.) were enhanced by lesions of the nucleus accumbens or substantia nigra. Striatal lesions only affected the response to the lowest dose of amphetamine. Lesions of the tuberculum olfactorium were without effect on spontaneous or amphetamine induced responses. The results support the concept of a modulatory 5HT influence on nigro-striatal function, and suggest that 5HT in the nucleus accumbens has an antagonistic role with respect to dopamine function in this site.
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Baumgarten, H. G., Victor, S. J., Lowenberg, W.: Effect of intraventricular injection of 5,7-dihydroxytryptamine on regional tryptophan hydroxylase of rat brain. J. Neurochem. 21, 251–283 (1973)
Carter, C. J., Pycock, C. J.: A study of the sites of interaction between dopamine and 5-hydroxytryptamine for the production of fluphenazine-induced catalepsy. Naunyn-Schmiedeberg's Arch. Pharmacol. 304, 135–139 (1978a)
Carter, C. J., Pycock, C. J.: Differential effects of central serotonin manipulation on hyperactive and stereotyped behaviour. Life Sci. 23, 953–960 (1978b)
Costall, B., Naylor, R. J.: On the mode of action of apomorphine. Eur. J. Pharmacol. 21, 350–361 (1973)
Costall, B., Kelly, D. M., Naylor, R. J.: Nomifensine: A potent dopaminergic agonist of antiparkinson potential. Psychopharmacologia (Berl.) 41, 153–164 (1975)
Costall, B., Marsden, C. D., Naylor, R. J., Pycock, C. J.: Stereotyped behaviour patterns and hyperactivity induced by amphetamine and apomorphine after discrete 6-hydroxydopamine lesions of extrapyramidal and mesolimbic nuclei. Brain Res. 123, 89–111 (1977)
Curzon, G., Green, A. R.: Rapid method for the determination of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in small regions of rat brain. Br. J. Pharmacol. 39, 633–655 (1970)
De Groot, J.: The rat forebrain in stereotaxic coordinates. Vehr. K. Ned. Akad. Wet. 52, 14–39 (1959)
Dray, A., Gonye, T. J., Oakley, N. R., Tanner, T.: Evidence for the existence of a raphé projection to the substantia nigra in rat. Brain Res. 113, 45–57 (1976)
Horton, R. W., Chapman, A. G., Meldrum, B. A.: Regional changes in cerebral GABA concentrations and convulsions produced by d- and l-allylglycine. J. Neurochem. 30, 1501–1504 (1978)
Kelly, P. H., Seviour, P. W., Iversen, S. D.: Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum. Brain Res. 94, 507–522 (1975)
Kostowski, W., Gumulka, W., Czlonkowski, A.: Reduced cataleptogenic effects of some neuroleptics in rats with lesioned midbrain raphé and pretreated with parachlorophenyl-alanine. Brain Res. 48, 434–446 (1972)
Laverty, R.: On the roles of dopamine and noradrenaline in animal behaviour. Prog. Neurobiol. 3, 33–69 (1974)
Marsden, C. A., Curzon G.: Effects of p-chlorophenylalanine and α-methyltryptophan on behaviour and brain 5-hydroxyindoles. Neuropharmacology 16, 489–494 (1977)
Pycock, C. J., Horton, R. W.: Dopamine dependent hyperactivity in the rat following manipulation of GABA mechanisms in the region of the nucleus accumbens. J. Neural. Transm. 45, 17–33 (1979)
Scheel-Krüger, J., Cools, A. R., van Wel, P. M.: Muscimol a GABA agonist injected into the nucleus accumbens increases apomorphine stereotypy and decreases the motility. Life Sci. 21, 1697–1702 (1977)
Segal, D. S.: Differential effects of para-chlorophenylalanine on amphetamine induced locomotion and stereotypy. Brain Res. 116, 267–276 (1976)
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Carter, C.J., Pycock, C.J. The effects of 5,7-dihydroxytryptamine lesions of extrapyramidal and mesolimbic sites on spontaneous motor behaviour, and amphetamine-induced stereotypy. Naunyn-Schmiedeberg's Arch. Pharmacol. 308, 51–54 (1979). https://doi.org/10.1007/BF00499718
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DOI: https://doi.org/10.1007/BF00499718