Summary
Tetanus toxin was injected at various doses (0.1–10,000 mouse MLD/kg) into the gastrocnemius muscle of the left hind leg of the cat. The relative excitability of the monosynaptic reflex (MSR) was increased in the very early period of the intoxication decreased in the later period, during which the MSR of the gastrocnemius was either partially or totally depressed at doses as low as 10 mouse MLD/kg.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Acheson GH, Ratnoff OD, Schoenbach EB (1942) The localized action on the spinal cord of intramuscularly injected tetanus toxin. J Exp Med 75:465–480
Bigalke H, Ahnert-Hilger S, Habermann E (1981a) Tetanus toxin and botulinum A toxin inhibit acetylcholine release from but not calcium uptake into brain tissue. Naunyn-Schmiedeberg's Arch Pharmacol 316:143–148
Bigalke H, Heller I, Bizzini B, Habermann E (1981b) Tetanus toxin and botulinum A toxin inhibit release and uptake of various transmitters, as studied with particulate preparations from rat brain and spinal cord. Naunyn-Schmiedeberg's Arch Pharmacol 316:244–251
Brooks VB, Curtis DR, Eccles JC (1957) The action of tetanus toxin on the inhibition of motoneurones. J Physiol (Lond) 135:655–672
Davies JR, Morgan RS, Wright EA, Wright GP (1954) The effect of local tetanus intoxication on the hind limb reflexes of the rabbit. Arch Int Physiol 62:248–263
Fildes P (1929) Bacillus tetani. In: Fildes P (ed) A system of bacteriology in relation to medicine, vol 3, Chap X. H. M. Stationary Office, London, pp 298–372
Granit R (1970) The basis of motor control. Academic Press, London New York
Kanda K (1980) Electrophysiological evidence for the anterograde transport of tetanus toxin across dorsal root. Proc IUPS 14:501
Kanda K, Takano K (1983) Effect of tetanus toxin on the excitatory and the inhibitory post-synaptic potentials in the cat motoneurone. J Physiol (Lond) 335:319–333
Lloyd DPC (1943) Reflex action in relation to pattern and peripheral source of afferent stimulation. J Neurophysiol 6:111–119
Mellanby J, Green J (1981) Commentary. How does tetanus toxin act? Neuroscience 6:281–300
Mikhailov VV, Shvarts IL (1969) Microphysiological analysis of electrical activity of spinal neurons of various types in experimental tetanus. Byull Exp Biol Med 68:20–23
Rushworth G (1960) Spasticity and rigidity: an experimental study and review. J Neurol Neurosurg Psychiatr 23:99–118
Sverdlov YS (1960) The spinal cord reflex activity under local tetanus (electrophysiological study). J Physiol USSR 46:941–947 (in russian)
Takano K (1976a) The effects of tetanus toxin on the extensor and flexor muscles of the hind leg of the cat. In: Ohsaka A, Hayashi K, Sawai Y (eds) Animal, plant, and microbial toxins, vol 2. Plenum Press, New York, pp 363–378
Takano K (1976b) Local tetanism a tool for understanding the stretch reflex. In: Homma S (ed) Progress in brain research, understanding the stretch reflex, vol 44. Elsevier, Amsterdam, pp 491–502
Takano K, Henatsch H-D (1973) Tension-extension diagram of the tetanus intoxicated muscle of the cat. Naunyn-Schmiedeberg's Arch Pharmacol 276:421–436
Takano K, Kanda K (1981) Effect of tetanus toxin on excitatory and inhibitory synapses of the motoneurones in the spinal cord. In: Szentagothai J, Palkovits M (eds) Regulatory functions of the CNS. Motion and organization principles, vol 1. Adv Physiol Sci, Pergamon Press, Oxford, pp 105–108
Takano K, Kirchner F, Terhaar P, Tiebert B (1978) Effect of tetanus toxin on the inhibition and excitation in the spinal cord during the experimental local tetanus. Abstr 5th Internat Conf on Tetanus, Ronneby
Takano K, Kanda K, Kirchner F, Kretzschmar H, Mizote M, Terhaar P (1980) Effect of tetanus toxin in the excitatory transmission of the motoneurone and other synapses in the motor system. In: Eaker D, Wadström T (eds) Natural toxins. Pergamon Press, Oxford, pp 607–614
Takano K, Kanda K, Kirchner F, Terhaar P, Tiebert B, Mizote M (1982) Blocking effect of tetanus toxin on the excitatory synapse on the motoneurone of the spinal cord. Proc 6th Internat Conf on Tetanus, Lyon Collection Fondation Merieux, pp 83–89
Terhaar P, Tiebert B, Kirchner F, Takano K (1977) Monosynaptic reflex during local tetanus. Pflügers Arch 368:R35
Tiebert B, Terhaar P, Kirchner F, Takano K (1977) Presynaptic inhibition during local tetanus. Pflügers Arch 368:R36
Wilson VJ, Diecke FPJ, Talbot WH (1960) Action of tetanus toxin on conditioning of spinal motoneurons. J Neurophysiol 23:659–666
Zacks I, Sheff MF (1970) Tetanism: Pathobiological aspects of the action of tetanus toxin in the nervous system and skeletal muscle. Neurosci Res 3:209–287
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Takano, K., Kirchner, F., Terhaar, P. et al. Effect of tetanus toxin on the monosynaptic reflex. Naunyn-Schmiedeberg's Arch. Pharmacol. 323, 217–220 (1983). https://doi.org/10.1007/BF00497666
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00497666