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Caudal ventrolateral medulla

A region responsible for the mediation of vasopressin-induced pressor responses

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Summary

We localized glutamate-sensitive sites in the ventrolateral medulla of the rat with the spinal cord cut at C1. When unilaterally injected into a circumscribed region of the caudal ventrolateral medulla,l-glutamate (30–300 ng) elicited a dose-dependent increase in arterial pressure. The pressor response was accounted for by an increased release of vasopressin because it was abolished by the intravenous injection of a vasopressin antagonist. Bilateral microinjections of kainic acid (50 ng) into the ventrolateral glutamate-sensitive area markedly reduced a vasopressin-induced pressor response to kainic acid (30 ng), injected bilaterally into the nucleus tractus solitarii. It is concluded that the glutamate-sensitive neurons in the caudal ventrolateral medulla are involved in mediation of the vasopressin-induced pressor response arising from the nucleus tractus solitarii.

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Authors and Affiliations

  1. Department of Pharmacology, Yokohama City University School of Medicine, Urafunecho, Minami-ku, 232, Yokohama, Japan

    T. Kubo, H. Amano & Y. Misu

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  1. T. Kubo
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  2. H. Amano
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  3. Y. Misu
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Kubo, T., Amano, H. & Misu, Y. Caudal ventrolateral medulla. Naunyn-Schmiedeberg's Arch. Pharmacol. 328, 368–372 (1985). https://doi.org/10.1007/BF00692902

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  • DOI: https://doi.org/10.1007/BF00692902

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