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Stimulation of central alpha-2 adrenoceptors inhibits gastric secretion in rats by releasing vasopressin

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Summary

The mechanism of the gastric antisecretory action of the stimulation of central alpha-2 adrenoceptors were studied in conscious, pylorus-ligated rats using intracerebroventricularly (i.c.v.) administered oxymetazoline as the model substance. I.c.v. administration of 10 μg of oxymetazoline strongly inhibited the secretion of acid, pepsin and fluid, whereas upon s.c. injection this dose was without any effect. Pretreatment with idazoxan abolished the antisecretory effect of i.c.v. administered oxymetazoline. I.c.v. injected oxymetazoline inhibited gastric secretion induced by carbachol in vagotomized rats, but the inhibitory effect was less pronounced than on the spontaneous secretion in rats with intact vagi. Hypophysectomy abolished the antisecretory effect of i.c.v. oxymetazoline, and pretreatment with the vasopressin antagonist, d(CH2)5Tyr(Me)AVP, significantly attenuated it. The results suggest that the inhibition of gastric secretion by the stimulation of central alpha-2 adrenoceptors in rats is mediated in part by vasopressin released from the pituitary gland.

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References

  • Anson ML, Mirsky AE (1932) The estimation of pepsin with haemogloin. J Gen Physiol 16:59–63

    Google Scholar 

  • Brodie DA, Lotti VJ, Bauer BG (1970) Drug effects on gastric secretion and stress gastric hemorrhage in the rat. Dig Dis 15:111–120

    Google Scholar 

  • Caltabiano S, Brennan FT, Kinter LB (1987) In vitro inhibition of gastric acid secretion by vasopressin. Eur J Pharmacol 139:281–286

    Google Scholar 

  • Canfield P, Price C (1984) The effect of sympathomimetic agents on gastric acid secretion in rats. Scand J Gastroenterol 19 (Suppl 89):23–26

    Google Scholar 

  • Cheng HC, Gleason EM, Nathan BA, Lachmann PJ, Woodward JK (1981) Effects of clonidine on gastric acid secretion in the rat. J Pharmacol Exp Ther 217:121–126

    Google Scholar 

  • Daly MJ (1984) The classification of adrenoceptors and their effects on gastric acid secretion. Scand J Gastroenterol 19:(Suppl 89):3–10

    Google Scholar 

  • Del Tacca M, Soldani G, Bernardini C, Martinotti E, Impicattiore M (1982) Pharmacological studies on the mechanism underlying the inhibitory and excitatory effects of clonidine on gastric acid secretion. Eur J Pharmacol 81:255–261

    Google Scholar 

  • DiJoseph JF, Taylor JA, Nabi Mir G (1984) Alpha-2 receptors in the gastrointestinal system: A new therapeutic approach. Life Sci 35:1031–1042

    Google Scholar 

  • Guth PH, Leung FW (1987) Physiology of the gastric circulation. In: Johnson LR (ed) Physiology of the gastrointestinal tract, 2nd edn. Raven Press, New York, pp 1031–1053

    Google Scholar 

  • Jacobson ED, Linford RH, Grossman MI (1966) Gastric secretion in relation to mucosal blood flow studied by a clearance technique. J Clin Invest 45:1–13.

    Google Scholar 

  • Jennewein HM (1977) The effect of clonidine on gastric acid secretion in rats and dogs. Naunyn-Schmiedeberg's Arch Pharmacol 297:85–90

    Google Scholar 

  • Lawson LJ, Dragstedt LR (1964) Vasopressin and gastric secretion. Surg Forum 15:118–120

    Google Scholar 

  • Limlomwongse L, Nophakoon J, Thithapandha A (1976) Mechanism of inhibition of gastric acid secretion by hypertonic solutions and vasopressin. Pflügers Arch 366:159–165

    Google Scholar 

  • Malta E, Ong JSB, Raper C, Tawa PE, Vaughan GN (1980) Structure-activity relationships of clonidine- and tolazoline-like compounds at histamine and alpha-adrenoceptor sites. Br J Pharmacol 69:679–688

    Google Scholar 

  • Manning M (1982) Antagonism of vasopressor and antidiuretic response to arginine vasopressin. Ann Intern Med 96:520–522

    Google Scholar 

  • Nakadate T, Nakaki T, Muraki T, Kato R (1982) Inhibitory alpha-2 adrenergic mechanism regulating gastric secretion in pylorusligated rats. Naunyn-Schmiedeberg's Arch Pharmacol 320: 170–174

    Google Scholar 

  • Osumi Y, Ishikawa T, Okuma Y, Nagasaka Y, Fujiwara M (1981) Inhibition of gastric functions by stimulation of the rat locus coeruleus. Eur J Pharmacol 75:27–35

    Google Scholar 

  • Osumi Y, Nagasaka Y, Wang Fu LH, Fujiwara M (1978) Inhibition of gastric acid secretion and mucosal blood flow induced by intracerebroventricularly applied neurotensin in rats. Life Sci 23:2275–2280

    Google Scholar 

  • Paakkari I (1980) A simple method for the verification of a successful cannulation of the rat cerebral ventricles. Experientia 36:887–888

    Google Scholar 

  • Pascaud X, Roger Y, Genton M, Rozé C (1982) Further support for the central origin of the gastric antisecretory properties of clonidine in conscious rats. Eur J Pharmacol 86:247–257

    Google Scholar 

  • Puurunen J (1985) Role of putative neurotransmitters in the central gastric antisecretory effect of prostaglandin E2 in rats. Br J Pharmacol 85:213–221

    Google Scholar 

  • Puurunen J, Leppäluoto J (1984) Centrally administered PGE2 inhibits gastric secretion in the rat by releasing vasopressin. Eur J Pharmacol 104:145–150

    Google Scholar 

  • Puurunen J, Westermann E (1978) Osmotic stimulation of pepsin secretion in the rat. Naunyn-Schmiedeberg's Arch Pharmacol 304:63–67

    Google Scholar 

  • Rozé C, Dubrasquet M, Chariot J, Vaille C (1980) Central inhibition of basal pancreatic and gastric secretion by beta-endorphin in rats. Gastroenterology 79:659–664

    Google Scholar 

  • Ruoff H-J, Wagner M, Günther C, Maslinski S (1982) Adrenergic stimulation of isolated rat gastric mucosal cells. Effect on adenylate cyclase and C-aminopyrine uptake. Naunyn-Schmiedeberg's Arch Pharmacol 320:175–181

    Google Scholar 

  • Sánches-Franco F, Cacicedo L, Vasallo JL, Blazquez JL, Munos Barragan L (1986) Arginine-vasopressin immunoreactive material in the gastrointestinal tract. Histochemistry 85:419–422

    Google Scholar 

  • Schapiro H, Wruble LD, Britt LG (1970) The effect of hypophysectomy on the gastrointestinal tract. A review of the literature. Dig Dis 15:1019–1030

    Google Scholar 

  • Sklar AH, Schrier RW (1983) Central nervous system mediators of vasopressin release. Physiological Rev 63:1243–1280

    Google Scholar 

  • Tache Y (1987) Brain control on gastric acid secretion. In: Johnson LR (ed) Physiology of the gastrointestinal tract, 2nd edn. Raven Press, New York, pp 911–930

    Google Scholar 

  • Taché Y, Collu R (1982) CNS mediated inhibition of gastric secretion by bombesin: independence from interaction with brain catecholaminergic, and serotoninergic pathways and pituitary hormones. Reg Peptides 3:51–59

    Google Scholar 

  • Taché Y, Lesiege D, Vale W, Collu R (1985) Gastric hypersecretion by intracisternal TRH: Dissociation from hypophysiotropic activity and role of central catecholamines. Eur J Pharmacol 107:149–155

    Google Scholar 

  • Timmermans PBMWM, de Jonge A, Thoolen MJMC, Wilffert B, Batink H, van Zwieten PA (1984) Quantitative relationships between alpha-adrenergic activity and binding affinity of alpha adrenoceptor agonists and antagonists. J Med Chem 27:495–503

    Google Scholar 

  • Waynforth HB (1980) Hypophysectomy. In: Waynforth HB (ed) Experimental and surgical techique in the rat. Academic Press, London, pp 143–147

    Google Scholar 

  • Yokotani K, Muramatsu I, Jujiwara M (1984) Alpha-1 and alpha-2 type adrenoceptors involved in the inhibitory effect of splanchnic nerves on parasympathetically stimulated gastric acid secretion in rats. J Pharmacol Exp Ther 229:305–310

    Google Scholar 

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  1. Department of Pharmacology, University of Oulu, SF-90220, Oulu, Finland

    Juhani Puurunen

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  1. Juhani Puurunen
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Puurunen, J. Stimulation of central alpha-2 adrenoceptors inhibits gastric secretion in rats by releasing vasopressin. Naunyn-Schmiedeberg's Arch Pharmacol 337, 164–168 (1988). https://doi.org/10.1007/BF00169244

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  • DOI: https://doi.org/10.1007/BF00169244

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