Abstract
We have studied the effects of idazoxan in rat aorta and small mesenteric artery. In the aorta, idazoxan behaved as a partial agonist (pKA=6.30). Prazosin produced rightward shift (pA2=9.88) and steepening of the idazoxan curve. In contrast, idazoxan had no effect of basal tension in the mesenteric artery, but shifted the noradrenaline curve to the right in a parallel manner (pA2=6.12). The selective al-adrenoceptor agonist, indanidine, also behaved as a partial agonist in the aorta and produced no significant contractions of the small mesenteric artery. Since idazoxan and indanidine have been reported to raise blood pressure in the pithed rat via an action at vascular α1-adrenoceptors, these results call into question the reliability of the small mesenteric artery assay as a predictor for α1-adrenoceptor-mediated pressor activity in vivo.
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Van der Graaf, P.H., Shankley, N.P. & Black, J.W. Analysis of the action of idazoxan calls into question the reliability of the rat isolated small mesenteric artery assay as a predictor for α1-adrenoceptor-mediated pressor activity. Naunyn-Schmiedeberg's Arch Pharmacol 354, 389–392 (1996). https://doi.org/10.1007/BF00171074
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DOI: https://doi.org/10.1007/BF00171074