Summary
In rats micro-injections in corpus striatum of quaternary chlorpromazine and related drugs give rise to highly characteristic neuroleptic effects: antagonism of amphetamine-induced stereotyped behaviour and development of catalepsy. There is no effect of injections in hippocampus or septum. Dopaminergic mechanisms in corpus striatum seem to play a central role in neuroleptic action.
This is a preview of subscription content, log in via an institution to check access.
References
Andén, N.-E., B.-E. Roos, and B. Werdinius: Effects of chlorpromazine, haloperidol and reserpine on the levels of phenolic acids in rabbit corpus striatum. Life Sci. 3, 149–158 (1964).
—, A. Dahlström, K. Fuxe, and K. Larsson: Functional role of the nigro-neo-striatal dopamine neurons. Acta pharmacol. (Kbh.) 24, 263–274 (1966).
Fisher, A. E., and R. A. Levitt: Drinking, induced by carbachol: thirst circuit or ventricular modification ? Science 157, 839–841 (1967).
Fog, R. L., A. Randrup, and H. Pakkenberg: Amines in the corpus striatum associated with the effects of both amphetamine and antipsychotic drugs. IV. World Congress of Psychiatry, Madrid. Excerpta Medica International Congress Series No. 150, Amsterdam. 715–717 (1968).
— —, and H. Pakkenberg: Aminergic mechanisms in corpus striatum and amphetamine-induced. stereotyped behaviour. Psychopharmacologia (Berl.) 11, 179–183 (1967).
Fuxe, K., and N.-E. Andén: Studies on central monoamine neurons with special reference to the nigro-neostriatal dopamine neuron system. In Biochemistry and Pharmacology of the Basal Ganglia. E. Costa, L. Coté, and M. Yahr, Eds., p. 123. New York: Raven Press Hewlett 1966.
Janssen, C. Niemegeers, and K. Schellekens: Is it possible to predict the clinical effects of neuroleptic drugs (major tranquillers) from animal data ? Drug Res. (Arzneimittel-Forsch.) 15, 104–117 (1965).
Munkvad, I., and A. Randrup: The persistence of amphetamine stereotypies of rats in spite of strong sedation. Acta psychiat. scand., suppl. 191 (ad vol. 42), 178–187 (1966).
Nueten, J.-M. van: Etude des effets de dérivés phénothiaziniques et butyrophénoniques sur l'action de l'amphétamine chez le rat; theses Paris 1962.
Prada, M. da, and A. Pletscher: On the mechanism of chlorpromazine-induced changes of cerebral homovanillic acid levels. J. Pharm. Pharmacol. 18, 628–630 (1966).
Randrup, A., and I. Munkvad: Special antagonism of amphetamine-induced abnormal behaviour. Psychopharmacologia (Berl.) 7, 416–422 (1965).
—, and J. Scheel-Krüger: Diethyldithiocarbamate and amphetamine stereotype behaviour. J. Pharm. Pharmacol. 18, 752 (1966).
—, and W. Jonas: Brain dopamine and the amphetamine-reserpine interaction. J. Pharm. Pharmacol. 19, 483–484 (1967).
—, and I. Munkvad: Behavioural stereotypies induced by pharmacological agents. Pharmacopsychiat. (Stuttg.) 1, 18–26 (1968).
Rossum, J. van: The significance of dopamine-receptor blockade for the mechanism of action of neuroleptic drugs. Arch. int. Pharmacodyn. 160 (2), 492–494 (1966).
Routtenberg, A.: Drinking induced by carbachol: thirst circuit or ventricular modification? Science 157, 838–839 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fog, R.L., Randrup, A. & Pakkenberg, H. Neuroleptic action of quaternary chlorpromazine and related drugs injected into various brain areas in rats. Psychopharmacologia 12, 428–432 (1968). https://doi.org/10.1007/BF00401348
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00401348